Heritability of young- and old-onset ischaemic stroke

A. Bluher, W. J. Devan, E. G. Holliday, M. Nalls, S. Parolo, S. Bione, A. K. Giese, G. B. Boncoraglio, J. M. Maguire, M. Müller-Nurasyid, C. Gieger, James F Meschia, J. Rosand, A. Rolfs, S. J. Kittner, B. D. Mitchell, J. R. O'Connell, Y. C. Cheng

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Abstract

Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age <55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P <0.001) and 34% (±10%, P <0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.

Original languageEnglish (US)
Pages (from-to)1488-1491
Number of pages4
JournalEuropean Journal of Neurology
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2015

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Keywords

  • Heritability
  • Ischemic stroke
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Bluher, A., Devan, W. J., Holliday, E. G., Nalls, M., Parolo, S., Bione, S., Giese, A. K., Boncoraglio, G. B., Maguire, J. M., Müller-Nurasyid, M., Gieger, C., Meschia, J. F., Rosand, J., Rolfs, A., Kittner, S. J., Mitchell, B. D., O'Connell, J. R., & Cheng, Y. C. (2015). Heritability of young- and old-onset ischaemic stroke. European Journal of Neurology, 22(11), 1488-1491. https://doi.org/10.1111/ene.12827