HEREDITARER MORBUS PARKINSON: BERICHT UBER DREI FAMILIEN MIT AUTOSOMAL-DOMINANTEM ERBGANG

Translated title of the contribution: Hereditary Parkinson's disease: Report on three families with autosomal-dominant inheritance pattern

Z. K. Wszolek, M. Cordes, D. B. Calne, M. D. Munter, I. Cordes, R. F. Pfeifer

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We have studied three families whose ancestors immigrated to North America from contiguous regions of northern Germany and southern Denmark. The pedigrees contain 77,206 and 376 individuals spanning 6, 7 and 8 generations with 7,7 and 11 affected members, respectively. Autosomal dominant inheritance pattern is present in two families and probable in the third. Typical L-dopa-responsive parkinsonism with bradykinesia, rigidity, resting tremor, and impaired postural reflexes uniformly develop in affected individuals from all three families. Further research on these three families, including genetic, pathologic and clinical examinations is planned.

Translated title of the contributionHereditary Parkinson's disease: Report on three families with autosomal-dominant inheritance pattern
Original languageGerman
Pages (from-to)331-335
Number of pages5
JournalNervenarzt
Volume64
Issue number5
StatePublished - Jan 1 1993

Keywords

  • Parkinson's disease
  • inherited parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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    Wszolek, Z. K., Cordes, M., Calne, D. B., Munter, M. D., Cordes, I., & Pfeifer, R. F. (1993). HEREDITARER MORBUS PARKINSON: BERICHT UBER DREI FAMILIEN MIT AUTOSOMAL-DOMINANTEM ERBGANG. Nervenarzt, 64(5), 331-335.