Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis

Peter J Dyck, William J Litchy, Sharon Minnerath, Thomas D. Bird, Phillip F. Chance, Daniel J Schaid, Arnold E. Aronson

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

We describe two kindreds with an autosomal dominant inherited disorder characterized by a variable degree of muscle weakness of limbs, vocal cords, and intercostal muscles and by asymptomatic sensory loss, beginning in infancy or childhood in severely affected persons. Life expectancy in severely affected patients is shortened because of respiratory failure. Because nerve conduction velocities are normal and it is an inherited axonal neuropathy, we classify the disorder as a variety of hereditary motor and sensory neuropathy type II (HMSN II) (HMSN IIc). The present report provides further evidence for heterogeneity among the hereditary motor and sensory neuropathy type II disorders. In one large pedigree with the type IIc disorder, no linkage to DNA markers known to map near the HMSN IA locus on chromosome 17p or the HMSN IB locus on chromosome 1q was demonstrated.

Original languageEnglish (US)
Pages (from-to)608-615
Number of pages8
JournalAnnals of Neurology
Volume35
Issue number5
DOIs
StatePublished - May 1994

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Hereditary Sensory and Motor Neuropathy
Charcot-Marie-Tooth Disease
Vocal Cord Paralysis
Diaphragm
Chromosomes
Intercostal Muscles
Laryngeal Muscles
Vocal Cords
Neural Conduction
Muscle Weakness
Pedigree
Life Expectancy
Genetic Markers
Respiratory Insufficiency
Extremities

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis. / Dyck, Peter J; Litchy, William J; Minnerath, Sharon; Bird, Thomas D.; Chance, Phillip F.; Schaid, Daniel J; Aronson, Arnold E.

In: Annals of Neurology, Vol. 35, No. 5, 05.1994, p. 608-615.

Research output: Contribution to journalArticle

Dyck, Peter J ; Litchy, William J ; Minnerath, Sharon ; Bird, Thomas D. ; Chance, Phillip F. ; Schaid, Daniel J ; Aronson, Arnold E. / Hereditary motor and sensory neuropathy with diaphragm and vocal cord paresis. In: Annals of Neurology. 1994 ; Vol. 35, No. 5. pp. 608-615.
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