TY - JOUR
T1 - Hereditary hypertrophic neuropathy in the trembler mouse. Part 1. Histopathological studies
T2 - Light microscopy
AU - Low, P. A.
N1 - Funding Information:
This work was supported by grants from the National Health and Medical Research Council of Australia, and from the Postgraduate Medical Foundation, University of Sydney.
PY - 1976/12
Y1 - 1976/12
N2 - The Trembler mouse suffers from a dominantly inherited chronic hypertrophic neuropathy. Quantitative light-microscopic studies have been performed on Trembler peripheral nerves from birth to adulthood, and compared with the findings in agematched control mice. Teased fibres of Trembler nerves contained virtually no myelin, nodes of Ranvier were difficult to identify, and supernumerary Schwann cells were prominent. Results of quantitative studies performed on the dorsal root ganglia and spinal cord of Trembler mice did not differ from those in controls. The density of myelinated fibres in the case of Tremblers was reduced at all ages when compared with controls, and there was a predominant loss of large diameter fibres.
AB - The Trembler mouse suffers from a dominantly inherited chronic hypertrophic neuropathy. Quantitative light-microscopic studies have been performed on Trembler peripheral nerves from birth to adulthood, and compared with the findings in agematched control mice. Teased fibres of Trembler nerves contained virtually no myelin, nodes of Ranvier were difficult to identify, and supernumerary Schwann cells were prominent. Results of quantitative studies performed on the dorsal root ganglia and spinal cord of Trembler mice did not differ from those in controls. The density of myelinated fibres in the case of Tremblers was reduced at all ages when compared with controls, and there was a predominant loss of large diameter fibres.
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U2 - 10.1016/0022-510X(76)90138-6
DO - 10.1016/0022-510X(76)90138-6
M3 - Article
C2 - 187739
AN - SCOPUS:0017151543
SN - 0022-510X
VL - 30
SP - 327
EP - 341
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 2-3
ER -