Hereditary demyelinating neuropathy in the Trembler mouse

P. A. Low; J. G. McLeod

doi:10.1016/0022-510X(75)90057-X

Hereditary demyelinating neuropathy in the Trembler mouse

P. A. Low, J. G. McLeod

Neurology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

Original language	English (US)
Pages (from-to)	565-574
Number of pages	10
Journal	Journal of the neurological sciences
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/0022-510X(75)90057-X
State	Published - Dec 1975

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Hereditary demyelinating neuropathy in the Trembler mouse",

abstract = "The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.",

author = "Low, {P. A.} and McLeod, {J. G.}",

note = "Funding Information: This work was supported by grants from the National Health and Medical Research Council of Australia, and from the Postgraduate Medical Foundation, University of Sydney.",

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N2 - The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

AB - The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

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Hereditary demyelinating neuropathy in the Trembler mouse

Abstract

ASJC Scopus subject areas

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