Hereditary demyelinating neuropathy in the Trembler mouse

P. A. Low, J. G. McLeod

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

Original languageEnglish (US)
Pages (from-to)565-574
Number of pages10
JournalJournal of the neurological sciences
Issue number4
StatePublished - Dec 1975

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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