TY - JOUR
T1 - Hereditary Colorectal Polyposis and Cancer Syndromes
T2 - A Primer on Diagnosis and Management
AU - Kanth, Priyanka
AU - Grimmett, Jade
AU - Champine, Marjan
AU - Burt, Randall
AU - Samadder, N. Jewel
N1 - Funding Information:
Guarantor of Article: N. Jewel Samadder, MD, MS, MSc, FRCPC. Specific author contributions: Drs Samadder, Kanth, Burt, and Ms. Grimmett and Champine had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analyses. Study concept and design: N. Jewel Samadder, Priyanka Kanth, Randall Burt, Jade Grimmett, and Marjan Champine; acquisition, analysis, and interpretation of data: N. Jewel Samad-der, Priyanka Kanth, Randall Burt, Jade Grimmett, and Marjan Champine; drafting of the manuscript: N. Jewel Samadder, Priyanka Kanth, Randall Burt, Jade Grimmett, and Marjan Champine; critical revision of the manuscript for important intellectual content: N. Jewel Samadder, Priyanka Kanth, Randall Burt, Jade Grimmett, and Marjan Champine. Financial support: Th e study was funded by the National Cancer Institute, American Society for Gastrointestinal Endoscopy, American College of Gastroenterology, and the Huntsman Cancer Foundation. The funding sources did not play a role in the design, conduct, or reporting of the study or in the decision to submit the manuscript for publication. Support for this project was provided by NCI grants P01-CA073992 (R.W.B.), R01-CA040641 (R.W.B.), an Endoscopic Research Award from the American Society for Gastrointestinal Endoscopy (N.J.S.), and a junior faculty career development award from the American College of Gastroenterology (N.J.S.). Partial support for the shared Genetic counseling resource and this project was provided by the Huntsman Cancer Institute Cancer Center Support Grant P30CA042014 from the National Cancer institute and the Huntsman Cancer Foundation. Potential competing interests: Randall Burt is a consultant for Myriad Genetics and N. Jewel Samadder is a consultant for Cook Medical. The remaining authors declare no conflict of interest.
Publisher Copyright:
© 2017 by the American College of Gastroenterology.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.
AB - Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.
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U2 - 10.1038/ajg.2017.212
DO - 10.1038/ajg.2017.212
M3 - Review article
C2 - 28786406
AN - SCOPUS:85030625584
SN - 0002-9270
VL - 112
SP - 1509
EP - 1525
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 10
ER -