Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management

Priyanka Kanth, Jade Grimmett, Marjan Champine, Randall Burt, Niloy Jewel Samadder

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.

Original languageEnglish (US)
Pages (from-to)1509-1525
Number of pages17
JournalAmerican Journal of Gastroenterology
Volume112
Issue number10
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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