TY - JOUR
T1 - Hereditary Cancer Syndromes—A Primer on Diagnosis and Management, Part 2
T2 - Gastrointestinal Cancer Syndromes
AU - Samadder, N. Jewel
AU - Baffy, Noemi
AU - Giridhar, Karthik V.
AU - Couch, Fergus J.
AU - Riegert-Johnson, Douglas
N1 - Publisher Copyright:
© 2019
PY - 2019/6
Y1 - 2019/6
N2 - Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis.
AB - Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis.
UR - http://www.scopus.com/inward/record.url?scp=85066262252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066262252&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2019.01.042
DO - 10.1016/j.mayocp.2019.01.042
M3 - Review article
C2 - 31171120
AN - SCOPUS:85066262252
SN - 0025-6196
VL - 94
SP - 1099
EP - 1116
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 6
ER -