Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening

Niloy Jewel Samadder, Kory Jasperson, Randall W. Burt

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

Original languageEnglish (US)
Pages (from-to)734-747
Number of pages14
JournalDigestive Diseases and Sciences
Volume60
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Keywords

  • Colorectal cancer
  • Familial
  • FAP
  • Hereditary
  • Lynch
  • Screening

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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