Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening

Niloy Jewel Samadder, Kory Jasperson, Randall W. Burt

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

Original languageEnglish (US)
Pages (from-to)734-747
Number of pages14
JournalDigestive Diseases and Sciences
Volume60
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Adenomatous Polyposis Coli
Genetic Testing
Early Detection of Cancer
Colonic Neoplasms
Neoplasms
Guidelines

Keywords

  • Colorectal cancer
  • Familial
  • FAP
  • Hereditary
  • Lynch
  • Screening

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Hereditary and Common Familial Colorectal Cancer : Evidence for Colorectal Screening. / Samadder, Niloy Jewel; Jasperson, Kory; Burt, Randall W.

In: Digestive Diseases and Sciences, Vol. 60, No. 3, 01.03.2015, p. 734-747.

Research output: Contribution to journalReview article

@article{6799169287cc4f69b45dc8cb30228da2,
title = "Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening",
abstract = "Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 {\%} of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 {\%} of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.",
keywords = "Colorectal cancer, Familial, FAP, Hereditary, Lynch, Screening",
author = "Samadder, {Niloy Jewel} and Kory Jasperson and Burt, {Randall W.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1007/s10620-014-3465-z",
language = "English (US)",
volume = "60",
pages = "734--747",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Hereditary and Common Familial Colorectal Cancer

T2 - Evidence for Colorectal Screening

AU - Samadder, Niloy Jewel

AU - Jasperson, Kory

AU - Burt, Randall W.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

AB - Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

KW - Colorectal cancer

KW - Familial

KW - FAP

KW - Hereditary

KW - Lynch

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=84930160017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930160017&partnerID=8YFLogxK

U2 - 10.1007/s10620-014-3465-z

DO - 10.1007/s10620-014-3465-z

M3 - Review article

C2 - 25501924

AN - SCOPUS:84930160017

VL - 60

SP - 734

EP - 747

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 3

ER -