Abstract
Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.
Original language | English (US) |
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Pages (from-to) | 734-747 |
Number of pages | 14 |
Journal | Digestive diseases and sciences |
Volume | 60 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2015 |
Keywords
- Colorectal cancer
- FAP
- Familial
- Hereditary
- Lynch
- Screening
ASJC Scopus subject areas
- Physiology
- Gastroenterology