Abstract
Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 734-747 |
| Number of pages | 14 |
| Journal | Digestive Diseases and Sciences |
| Volume | 60 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2015 |
| Externally published | Yes |
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Keywords
- Colorectal cancer
- Familial
- FAP
- Hereditary
- Lynch
- Screening
ASJC Scopus subject areas
- Physiology
- Gastroenterology
Cite this
Hereditary and Common Familial Colorectal Cancer : Evidence for Colorectal Screening. / Samadder, Niloy Jewel; Jasperson, Kory; Burt, Randall W.
In: Digestive Diseases and Sciences, Vol. 60, No. 3, 01.03.2015, p. 734-747.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Hereditary and Common Familial Colorectal Cancer
T2 - Evidence for Colorectal Screening
AU - Samadder, Niloy Jewel
AU - Jasperson, Kory
AU - Burt, Randall W.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.
AB - Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6 % of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30 % of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.
KW - Colorectal cancer
KW - Familial
KW - FAP
KW - Hereditary
KW - Lynch
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=84930160017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930160017&partnerID=8YFLogxK
U2 - 10.1007/s10620-014-3465-z
DO - 10.1007/s10620-014-3465-z
M3 - Review article
C2 - 25501924
AN - SCOPUS:84930160017
VL - 60
SP - 734
EP - 747
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 3
ER -