Her patients never wake up on time fatal forty DDI: Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7

Toby N. Weingarten, Erica D. Wittwer, Wayne T. Nicholson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This is an example of one drug (diltiazem hydrochloride) suppressing hepatic metabolism of two other drugs (midazolam hydrochloride and alfentanil hydrochloride) through inhibition of several isoenzymes in the cytochrome P450 3A family.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Pages377-379
Number of pages3
ISBN (Print)9781461474951, 9781461474944
DOIs
StatePublished - Sep 15 2015

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Alfentanil
Cytochrome P-450 CYP3A
Diltiazem
Midazolam
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Isoenzymes
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Weingarten, T. N., Wittwer, E. D., & Nicholson, W. T. (2015). Her patients never wake up on time fatal forty DDI: Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 377-379). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_80

Her patients never wake up on time fatal forty DDI : Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7. / Weingarten, Toby N.; Wittwer, Erica D.; Nicholson, Wayne T.

A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. p. 377-379.

Research output: Chapter in Book/Report/Conference proceedingChapter

Weingarten, TN, Wittwer, ED & Nicholson, WT 2015, Her patients never wake up on time fatal forty DDI: Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7. in A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, pp. 377-379. https://doi.org/10.1007/978-1-4614-7495-1_80
Weingarten TN, Wittwer ED, Nicholson WT. Her patients never wake up on time fatal forty DDI: Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7. In A Case Approach to Perioperative Drug-Drug Interactions. Springer New York. 2015. p. 377-379 https://doi.org/10.1007/978-1-4614-7495-1_80
Weingarten, Toby N. ; Wittwer, Erica D. ; Nicholson, Wayne T. / Her patients never wake up on time fatal forty DDI : Midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7. A Case Approach to Perioperative Drug-Drug Interactions. Springer New York, 2015. pp. 377-379
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