Her-2/neu expression in ovarian cancer: Pre- and postexposure to platinum chemotherapy

Prema P. Peethambaram, William A. Cliby, Gregory Lubiniecki, Amy C. Clayton, Patrick C. Roche, Stephen J. Iturria, Lynn C. Hartmann, Ingegerd Hellström, Scott E. Strome

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Abstract

Objective. Our objective was to determine if the level of Her-2/neu expression in advanced ovarian cancer changed after platinum-based chemotherapy. Methods. Tissue samples from 43 patients who had surgery for ovarian cancer between 1991 and 2001 at the Mayo Clinic were stained for Her-2/neu expression using the DAKO kit and reviewed independently by two pathologists. Patient charts were reviewed for demographic data, clinical course, chemotherapy, and survival times. Results. Her-2/neu expression was 0 in 30 patients (69.76%), 1+ in 12 patients (27.9%), and 3+ in 1 patient (2.32%) before chemotherapy. After platinum chemotherapy, Her-2/neu expression changed from 0 to 1+ in 7 patients, from 1+ to 0 in 4 patients, 0 to 2+ in 1 patient, and 1+ to 2+ in 2 patients and no change was seen in 29 patients. Both pathologists agreed in all instances when the score was 0 or 1+ and disagreed in two instances between a negative and a weakly positive staining. Conclusions. Our findings indicate a low level of overexpression of Her-2/neu at the time of primary diagnosis of epithelial ovarian cancer. Relapsing tumors show no significant change in the intensity of Her-2/neu expression after platinum-based chemotherapy. Further prospective studies are needed to confirm these findings and to ascertain whether platinum chemotherapy indeed has no effect on Her-2/neu expression.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalGynecologic oncology
Volume89
Issue number1
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Peethambaram, P. P., Cliby, W. A., Lubiniecki, G., Clayton, A. C., Roche, P. C., Iturria, S. J., Hartmann, L. C., Hellström, I., & Strome, S. E. (2003). Her-2/neu expression in ovarian cancer: Pre- and postexposure to platinum chemotherapy. Gynecologic oncology, 89(1), 99-104. https://doi.org/10.1016/S0090-8258(03)00065-9