Hepcidin is a key mediator of anemia of inflammation in Crohn's disease

Robert J. Basseri, Elizabeta Nemeth, Maria E. Vassilaki, Benjamin Basseri, Pedram Enayati, Omid Shaye, Leonidas A. Bourikas, Tom Ganz, Konstantinos A. Papadakis

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Anemia often complicates the course of Inflammatory Bowel Disease (IBD). Hepcidin, a liver-produced peptide hormone, is a key mediator of anemia of chronic disease (ACD). We hypothesized that hepcidin is significantly elevated in anemic CD patients and that hepcidin may cause iron restriction and, therefore, mediate ACD. Methods: We enrolled 17 patients with CD and ACD recruited from the Cedars-Sinai IBD Center. Routine blood tests included hemoglobin (Hgb), hematocrit, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Anemia was defined as hemoglobin < 12. g/dL and < 13.5. g/dL, in men and women, respectively. ACD was diagnosed on the basis of a combination of the following: a) normal or elevated ferritin b) lowered serum iron and total iron binding capacity and c) normal percent iron saturation. Serum and urine hepcidin, as well as IL-6 levels were also measured. Patients with documented iron-deficiency anemia were excluded. Results: There was an excellent correlation between urine (expressed as ng/mg of creatinine) and serum hepcidin levels expressed as ng/ml (r = 0.853, p < 0.001). We also found a strong positive correlation between serum hepcidin and ferritin levels (r= 0.723, p= 0.0015). There was a positive correlation between serum hepcidin and IL-6 levels (r= 0.546, p= 0.023). We found a strong negative correlation between serum hepcidin concentrations and Hgb levels (r= 0.528, p= 0.029). Conclusion: We demonstrate that ACD in CD is characterized by high serum IL-6 and hepcidin levels, which negatively correlate with Hgb levels. Our data support the hypothesis that IL-6-driven hepcidin production mediates ACD in patients with CD.

Original languageEnglish (US)
Pages (from-to)e286-e291
JournalJournal of Crohn's and Colitis
Volume7
Issue number8
DOIs
StatePublished - Sep 1 2013

Keywords

  • Anemia
  • Anemia of chronic disease
  • Crohn's disease
  • Hepcidin

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Hepcidin is a key mediator of anemia of inflammation in Crohn's disease'. Together they form a unique fingerprint.

Cite this