Hepatocytes direct the formation of a pro-metastatic niche in the liver

Jae W. Lee, Meredith L. Stone, Paige M. Porrett, Stacy K. Thomas, Chad A. Komar, Joey H. Li, Devora Delman, Kathleen Graham, Whitney L. Gladney, Xia Hua, Taylor A. Black, Austin L. Chien, Krishna S. Majmundar, Jeffrey C. Thompson, Stephanie S. Yee, Mark H. O’Hara, Charu Aggarwal, Dong Xin, Abraham Shaked, Mingming GaoDexi Liu, Mitesh J Borad, Ramesk K Ramanathan, Erica L. Carpenter, Ailing Ji, Maria C. de Beer, Frederick C. de Beer, Nancy R. Webb, Gregory L. Beatty

Research output: Contribution to journalLetter

14 Citations (Scopus)

Abstract

The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour cells to the liver2,3. The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth. During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 (STAT3) signalling and increased production of serum amyloid A1 and A2 (referred to collectively as SAA). Overexpression of SAA by hepatocytes also occurs in patients with pancreatic and colorectal cancers that have metastasized to the liver, and many patients with locally advanced and metastatic disease show increases in circulating SAA. Activation of STAT3 in hepatocytes and the subsequent production of SAA depend on the release of interleukin 6 (IL-6) into the circulation by non-malignant cells. Genetic ablation or blockade of components of IL-6–STAT3–SAA signalling prevents the establishment of a pro-metastatic niche and inhibits liver metastasis. Our data identify an intercellular network underpinned by hepatocytes that forms the basis of a pro-metastatic niche in the liver, and identify new therapeutic targets.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalNature
Volume567
Issue number7747
DOIs
StatePublished - Mar 14 2019

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Hepatocytes
Liver
STAT3 Transcription Factor
Neoplasm Metastasis
Circulating Neoplastic Cells
Tropism
Myeloid Cells
Pancreatic Neoplasms
varespladib methyl
Amyloid
Liver Cirrhosis
Colorectal Neoplasms
Interleukin-6
Carcinogenesis
Serum
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Lee, J. W., Stone, M. L., Porrett, P. M., Thomas, S. K., Komar, C. A., Li, J. H., ... Beatty, G. L. (2019). Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature, 567(7747), 249-252. https://doi.org/10.1038/s41586-019-1004-y

Hepatocytes direct the formation of a pro-metastatic niche in the liver. / Lee, Jae W.; Stone, Meredith L.; Porrett, Paige M.; Thomas, Stacy K.; Komar, Chad A.; Li, Joey H.; Delman, Devora; Graham, Kathleen; Gladney, Whitney L.; Hua, Xia; Black, Taylor A.; Chien, Austin L.; Majmundar, Krishna S.; Thompson, Jeffrey C.; Yee, Stephanie S.; O’Hara, Mark H.; Aggarwal, Charu; Xin, Dong; Shaked, Abraham; Gao, Mingming; Liu, Dexi; Borad, Mitesh J; Ramanathan, Ramesk K; Carpenter, Erica L.; Ji, Ailing; de Beer, Maria C.; de Beer, Frederick C.; Webb, Nancy R.; Beatty, Gregory L.

In: Nature, Vol. 567, No. 7747, 14.03.2019, p. 249-252.

Research output: Contribution to journalLetter

Lee, JW, Stone, ML, Porrett, PM, Thomas, SK, Komar, CA, Li, JH, Delman, D, Graham, K, Gladney, WL, Hua, X, Black, TA, Chien, AL, Majmundar, KS, Thompson, JC, Yee, SS, O’Hara, MH, Aggarwal, C, Xin, D, Shaked, A, Gao, M, Liu, D, Borad, MJ, Ramanathan, RK, Carpenter, EL, Ji, A, de Beer, MC, de Beer, FC, Webb, NR & Beatty, GL 2019, 'Hepatocytes direct the formation of a pro-metastatic niche in the liver', Nature, vol. 567, no. 7747, pp. 249-252. https://doi.org/10.1038/s41586-019-1004-y
Lee JW, Stone ML, Porrett PM, Thomas SK, Komar CA, Li JH et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019 Mar 14;567(7747):249-252. https://doi.org/10.1038/s41586-019-1004-y
Lee, Jae W. ; Stone, Meredith L. ; Porrett, Paige M. ; Thomas, Stacy K. ; Komar, Chad A. ; Li, Joey H. ; Delman, Devora ; Graham, Kathleen ; Gladney, Whitney L. ; Hua, Xia ; Black, Taylor A. ; Chien, Austin L. ; Majmundar, Krishna S. ; Thompson, Jeffrey C. ; Yee, Stephanie S. ; O’Hara, Mark H. ; Aggarwal, Charu ; Xin, Dong ; Shaked, Abraham ; Gao, Mingming ; Liu, Dexi ; Borad, Mitesh J ; Ramanathan, Ramesk K ; Carpenter, Erica L. ; Ji, Ailing ; de Beer, Maria C. ; de Beer, Frederick C. ; Webb, Nancy R. ; Beatty, Gregory L. / Hepatocytes direct the formation of a pro-metastatic niche in the liver. In: Nature. 2019 ; Vol. 567, No. 7747. pp. 249-252.
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abstract = "The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour cells to the liver2,3. The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth. During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 (STAT3) signalling and increased production of serum amyloid A1 and A2 (referred to collectively as SAA). Overexpression of SAA by hepatocytes also occurs in patients with pancreatic and colorectal cancers that have metastasized to the liver, and many patients with locally advanced and metastatic disease show increases in circulating SAA. Activation of STAT3 in hepatocytes and the subsequent production of SAA depend on the release of interleukin 6 (IL-6) into the circulation by non-malignant cells. Genetic ablation or blockade of components of IL-6–STAT3–SAA signalling prevents the establishment of a pro-metastatic niche and inhibits liver metastasis. Our data identify an intercellular network underpinned by hepatocytes that forms the basis of a pro-metastatic niche in the liver, and identify new therapeutic targets.",
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AU - Lee, Jae W.

AU - Stone, Meredith L.

AU - Porrett, Paige M.

AU - Thomas, Stacy K.

AU - Komar, Chad A.

AU - Li, Joey H.

AU - Delman, Devora

AU - Graham, Kathleen

AU - Gladney, Whitney L.

AU - Hua, Xia

AU - Black, Taylor A.

AU - Chien, Austin L.

AU - Majmundar, Krishna S.

AU - Thompson, Jeffrey C.

AU - Yee, Stephanie S.

AU - O’Hara, Mark H.

AU - Aggarwal, Charu

AU - Xin, Dong

AU - Shaked, Abraham

AU - Gao, Mingming

AU - Liu, Dexi

AU - Borad, Mitesh J

AU - Ramanathan, Ramesk K

AU - Carpenter, Erica L.

AU - Ji, Ailing

AU - de Beer, Maria C.

AU - de Beer, Frederick C.

AU - Webb, Nancy R.

AU - Beatty, Gregory L.

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N2 - The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a ‘pro-metastatic’ niche that supports the spread of tumour cells to the liver2,3. The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth. During early pancreatic tumorigenesis in mice, hepatocytes show activation of signal transducer and activator of transcription 3 (STAT3) signalling and increased production of serum amyloid A1 and A2 (referred to collectively as SAA). Overexpression of SAA by hepatocytes also occurs in patients with pancreatic and colorectal cancers that have metastasized to the liver, and many patients with locally advanced and metastatic disease show increases in circulating SAA. Activation of STAT3 in hepatocytes and the subsequent production of SAA depend on the release of interleukin 6 (IL-6) into the circulation by non-malignant cells. Genetic ablation or blockade of components of IL-6–STAT3–SAA signalling prevents the establishment of a pro-metastatic niche and inhibits liver metastasis. Our data identify an intercellular network underpinned by hepatocytes that forms the basis of a pro-metastatic niche in the liver, and identify new therapeutic targets.

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