Hepatocyte liver-assist systems - A clinical update

Scott Nyberg, Sri Prakash Misra

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Liver failure is a serious problem that affects thousands of people in the United States each year. Other than liver transplantation, a supportive therapy has been unavailable for patients with liver failure that is refractory to medical treatment. An apparent solution to this problem is a hepatocyte liver-assist system. Such a system is composed of mammalian hepatocytes loaded in a mechanical apparatus, such as a hollow fiber cartridge. During extracorporeal perfusion of the system, the hepatocytes provide metabolic function to the patient with liver failure. At least two extracorporeal hepatocyte systems have shown promise in human clinical trials of acute liver failure. In fact, one system has gained approval from the Food and Drug Administration for testing in a randomized multicenter clinical trial. In this article, key issues of clinical testing are reviewed, and major contributions and questions that remain unresolved are emphasized.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalMayo Clinic Proceedings
Volume73
Issue number8
DOIs
StatePublished - Jan 1 1998

Fingerprint

Hepatocytes
Liver Failure
Liver
Acute Liver Failure
United States Food and Drug Administration
Liver Transplantation
Multicenter Studies
Randomized Controlled Trials
Perfusion
Clinical Trials
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hepatocyte liver-assist systems - A clinical update. / Nyberg, Scott; Misra, Sri Prakash.

In: Mayo Clinic Proceedings, Vol. 73, No. 8, 01.01.1998, p. 765-771.

Research output: Contribution to journalReview article

Nyberg, Scott ; Misra, Sri Prakash. / Hepatocyte liver-assist systems - A clinical update. In: Mayo Clinic Proceedings. 1998 ; Vol. 73, No. 8. pp. 765-771.
@article{2c7b56e30521435baf50e91b419a66ee,
title = "Hepatocyte liver-assist systems - A clinical update",
abstract = "Liver failure is a serious problem that affects thousands of people in the United States each year. Other than liver transplantation, a supportive therapy has been unavailable for patients with liver failure that is refractory to medical treatment. An apparent solution to this problem is a hepatocyte liver-assist system. Such a system is composed of mammalian hepatocytes loaded in a mechanical apparatus, such as a hollow fiber cartridge. During extracorporeal perfusion of the system, the hepatocytes provide metabolic function to the patient with liver failure. At least two extracorporeal hepatocyte systems have shown promise in human clinical trials of acute liver failure. In fact, one system has gained approval from the Food and Drug Administration for testing in a randomized multicenter clinical trial. In this article, key issues of clinical testing are reviewed, and major contributions and questions that remain unresolved are emphasized.",
author = "Scott Nyberg and Misra, {Sri Prakash}",
year = "1998",
month = "1",
day = "1",
doi = "10.4065/73.8.765",
language = "English (US)",
volume = "73",
pages = "765--771",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "8",

}

TY - JOUR

T1 - Hepatocyte liver-assist systems - A clinical update

AU - Nyberg, Scott

AU - Misra, Sri Prakash

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Liver failure is a serious problem that affects thousands of people in the United States each year. Other than liver transplantation, a supportive therapy has been unavailable for patients with liver failure that is refractory to medical treatment. An apparent solution to this problem is a hepatocyte liver-assist system. Such a system is composed of mammalian hepatocytes loaded in a mechanical apparatus, such as a hollow fiber cartridge. During extracorporeal perfusion of the system, the hepatocytes provide metabolic function to the patient with liver failure. At least two extracorporeal hepatocyte systems have shown promise in human clinical trials of acute liver failure. In fact, one system has gained approval from the Food and Drug Administration for testing in a randomized multicenter clinical trial. In this article, key issues of clinical testing are reviewed, and major contributions and questions that remain unresolved are emphasized.

AB - Liver failure is a serious problem that affects thousands of people in the United States each year. Other than liver transplantation, a supportive therapy has been unavailable for patients with liver failure that is refractory to medical treatment. An apparent solution to this problem is a hepatocyte liver-assist system. Such a system is composed of mammalian hepatocytes loaded in a mechanical apparatus, such as a hollow fiber cartridge. During extracorporeal perfusion of the system, the hepatocytes provide metabolic function to the patient with liver failure. At least two extracorporeal hepatocyte systems have shown promise in human clinical trials of acute liver failure. In fact, one system has gained approval from the Food and Drug Administration for testing in a randomized multicenter clinical trial. In this article, key issues of clinical testing are reviewed, and major contributions and questions that remain unresolved are emphasized.

UR - http://www.scopus.com/inward/record.url?scp=0031828754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031828754&partnerID=8YFLogxK

U2 - 10.4065/73.8.765

DO - 10.4065/73.8.765

M3 - Review article

VL - 73

SP - 765

EP - 771

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 8

ER -