Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease

Suzette J. Bielinski, Cecilia Berardi, Paul A. Decker, Nicholas B. Larson, Elizabeth J. Bell, James S. Pankow, Michele M. Sale, Weihong Tang, Naomi Q. Hanson, Christina L. Wassel, Mariza De Andrade, Matthew J. Budoff, Joseph F. Polak, Hugues Sicotte, Michael Y. Tsai

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective To determine if hepatocyte growth factor (HGF), a promising biomarker of coronary heart disease (CHD) given its release into circulation in response to endothelial damage, is associated with subclinical and clinical CHD in a racial/ethnic diverse population. Methods HGF was measured in 6738 participants of the Multi-Ethnic Study of Atherosclerosis (MESA). Highest mean HGF values (pg/mL) were observed in Hispanic, followed by African, non-Hispanic white, then Chinese Americans. Results In all races/ethnicities, HGF levels were associated with older age, higher systolic blood pressure (SBP) and body mass index, lower high-density lipoprotein, diabetes and current smoking. In fully adjusted models, each SD higher HGF was associated with an average increase in coronary artery calcium (CAC) of 55 Agatston units for non-Hispanic whites (p<0.001) and 51 Agatston units for African-Americans (p=0.007) but was not in the other race/ethnic groups (interaction p=0.02). There were 529 incident CHD events, and CHD risk was 41% higher in African (p<0.001), 17% in non-Hispanic white (p=0.026) and Chinese (p=0.36), and 6% in Hispanic Americans (p=0.56) per SD increase in HGF. Conclusion In a large and diverse population-based cohort, we report that HGF is associated with subclinical and incident CHD. We demonstrate evidence of racial/ethnic heterogeneity within these associations, as the results are most compelling in African-Americans and non-Hispanic white Americans. We provide evidence that HGF is a biomarker of atherosclerotic disease that is independent of traditional risk factors.

Original languageEnglish (US)
Pages (from-to)1185-1193
Number of pages9
JournalHeart
Volume103
Issue number15
DOIs
StatePublished - Aug 1 2017

Keywords

  • atherosclerosis
  • coronary disease
  • epidemiology
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Bielinski, S. J., Berardi, C., Decker, P. A., Larson, N. B., Bell, E. J., Pankow, J. S., Sale, M. M., Tang, W., Hanson, N. Q., Wassel, C. L., De Andrade, M., Budoff, M. J., Polak, J. F., Sicotte, H., & Tsai, M. Y. (2017). Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease. Heart, 103(15), 1185-1193. https://doi.org/10.1136/heartjnl-2016-310450