TY - JOUR
T1 - Hepatocyte growth factor and left ventricular geometry in end-stage renal disease
AU - The contribution of the CREED Investigators
AU - Malatino, Lorenzo S.
AU - Cataliotti, Alessandro
AU - Benedetto, Francesco A.
AU - Stancanelli, Benedetta
AU - Bellanuova, Ignazio
AU - Belluardo, Paola
AU - Bonaiuto, Lorena
AU - Tripepi, Giovanni
AU - Mallamaci, Francesca
AU - Castellino, Pietro
AU - Zoccali, Carmine
AU - Enia, Giuseppe
AU - Parlongo, Saverio
AU - Cutrupi, Sebastiano
AU - Panuccio, Vincenzo
AU - Marino, Carmela
AU - Tripepi, Rocco
AU - Di Vincenzo, Fernando
AU - Arena, Claudio
AU - Giacone, Giuseppe
AU - Cottini, Emilio
AU - Rapisarda, Francesco
AU - Fatuzzo, Pasquale
AU - Bonanno, Grazia
AU - Seminara, Giuseppe
AU - Candela, Vincenzo
AU - Labate, Carlo
AU - Tassone, Filippo
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Hepatocyte growth factor is a pleiotropic cytokine with cardioprotective properties. Its serum concentration is markedly raised in end-stage renal disease. This study assessed the relation of hepatocyte growth factor (HGF) with left ventricular mass and geometry in end-stage renal disease. Serum HGF measurements and echocardiographic studies were performed in 185 patients receiving hemodialysis. Patients with serum HGF above the median (1.85 ng/mL) had more frequent cardiovascular complications. This cytokine was directly related to mean left ventricular wall thickness (r=0.23, P=0.002) and relative wall thickness (r=0.25, P=0.0001); a multivariate analysis showed that this relation was independent of other risk factors. Accordingly, the prevalence of left ventricular concentric geometry (either concentric left ventricular hypertrophy or remodeling) was much higher (n=49, 53%) among patients with HGF values above the median that in those with values ≤1.85 ng/mL (n=31, 34%). Furthermore, the risk for left ventricular concentric geometry was higher in patients with HGF values above the median (odds ratio, 2.57; 95% CI, 1.33 to 4.98; P=0.005), and multiple logistic regression analysis confirmed that this association was independent of other risk factors. In patients receiving hemodialysis, elevated serum HGF is associated with concentric left ventricular geometry. This is consistent with reports that link this cytokine to arterial remodeling and survival in patients with end-stage renal disease and suggests that it is part of a counterregulatory response aimed at attenuating cardiovascular damage in this high-risk population.
AB - Hepatocyte growth factor is a pleiotropic cytokine with cardioprotective properties. Its serum concentration is markedly raised in end-stage renal disease. This study assessed the relation of hepatocyte growth factor (HGF) with left ventricular mass and geometry in end-stage renal disease. Serum HGF measurements and echocardiographic studies were performed in 185 patients receiving hemodialysis. Patients with serum HGF above the median (1.85 ng/mL) had more frequent cardiovascular complications. This cytokine was directly related to mean left ventricular wall thickness (r=0.23, P=0.002) and relative wall thickness (r=0.25, P=0.0001); a multivariate analysis showed that this relation was independent of other risk factors. Accordingly, the prevalence of left ventricular concentric geometry (either concentric left ventricular hypertrophy or remodeling) was much higher (n=49, 53%) among patients with HGF values above the median that in those with values ≤1.85 ng/mL (n=31, 34%). Furthermore, the risk for left ventricular concentric geometry was higher in patients with HGF values above the median (odds ratio, 2.57; 95% CI, 1.33 to 4.98; P=0.005), and multiple logistic regression analysis confirmed that this association was independent of other risk factors. In patients receiving hemodialysis, elevated serum HGF is associated with concentric left ventricular geometry. This is consistent with reports that link this cytokine to arterial remodeling and survival in patients with end-stage renal disease and suggests that it is part of a counterregulatory response aimed at attenuating cardiovascular damage in this high-risk population.
KW - Growth substances
KW - Hypertrophy
KW - Remodeling
KW - Renal disease
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U2 - 10.1161/01.HYP.0000046919.41112.4B
DO - 10.1161/01.HYP.0000046919.41112.4B
M3 - Article
C2 - 12511535
SN - 0194-911X
VL - 41
SP - 88
EP - 92
JO - Hypertension
JF - Hypertension
IS - 1
ER -