Hepatitis viruses: Hepatocellular carcinoma

Ju Dong Yang, Roongruedee Chaiteerakij, Lewis Rowland Roberts

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Liver cancer is the fifth most common cancer in men and the seventh in women. The estimated number of new liver cancer cases worldwide has increased by 70 % between 1990 and 2008. It has been projected that the number will increase by 30 % to one million new cases in 2020. Viral hepatitis is the most common cause of hepatocellular carcinoma (HCC) in the world. Hepatitis B virus (HBV) is the most common etiology of HCC in most Asian and African countries and accounts for more than half of all HCCs in the world. Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease and HCC in most Western countries including the USA. The prevalence of HCV infection has increased and the proportion of patients with liver cirrhosis or HCC from HCV has also increased in the USA over the past several decades. Carcinogenesis is a complex and multistep process involving a sequence of tumor initiation, promotion, and progression over several years. Common molecular mechanisms of HCC occurring in the cirrhotic liver include cell-cycle dysregulation, sustained angiogenesis, apoptosis resistance, and cellular immortalization through reactivation of telomerase reverse transcriptase.

Original languageEnglish (US)
Title of host publicationViral Infections of Humans: Epidemiology and Control
PublisherSpringer US
Pages785-804
Number of pages20
Volume9781489974488
ISBN (Print)9781489974488, 1489974474, 9781489974471
DOIs
StatePublished - Jun 1 2014

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Hepatitis Viruses
Hepatocellular Carcinoma
Hepacivirus
Virus Diseases
Liver Neoplasms
Telomerase
Hepatitis B virus
Liver Cirrhosis
Hepatitis
Liver Diseases
Neoplasms
Cell Cycle
Carcinogenesis
Chronic Disease
Apoptosis
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yang, J. D., Chaiteerakij, R., & Roberts, L. R. (2014). Hepatitis viruses: Hepatocellular carcinoma. In Viral Infections of Humans: Epidemiology and Control (Vol. 9781489974488, pp. 785-804). Springer US. https://doi.org/10.1007/978-1-4899-7448-8_34

Hepatitis viruses : Hepatocellular carcinoma. / Yang, Ju Dong; Chaiteerakij, Roongruedee; Roberts, Lewis Rowland.

Viral Infections of Humans: Epidemiology and Control. Vol. 9781489974488 Springer US, 2014. p. 785-804.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yang, JD, Chaiteerakij, R & Roberts, LR 2014, Hepatitis viruses: Hepatocellular carcinoma. in Viral Infections of Humans: Epidemiology and Control. vol. 9781489974488, Springer US, pp. 785-804. https://doi.org/10.1007/978-1-4899-7448-8_34
Yang JD, Chaiteerakij R, Roberts LR. Hepatitis viruses: Hepatocellular carcinoma. In Viral Infections of Humans: Epidemiology and Control. Vol. 9781489974488. Springer US. 2014. p. 785-804 https://doi.org/10.1007/978-1-4899-7448-8_34
Yang, Ju Dong ; Chaiteerakij, Roongruedee ; Roberts, Lewis Rowland. / Hepatitis viruses : Hepatocellular carcinoma. Viral Infections of Humans: Epidemiology and Control. Vol. 9781489974488 Springer US, 2014. pp. 785-804
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