TY - JOUR
T1 - Hepatitis G virus infection in american patients with cryptogenic cirrhosis
T2 - No evidence for liver replication
AU - Laskus, T.
AU - Wang, L. F.
AU - Radkowski, M.
AU - Sook Jin Jang, Jin Jang
AU - Vargas, H.
AU - Dudson, F.
AU - Fung, J.
AU - Rakela, J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - It is unclear whether hepatitis G virus (HGV) can lead to chronic liver disease and cirrhosis. Eighty-nine patients with end-stage liver disease undergoing liver transplantation were studied: 50 were diagnosed as having cryptogenic cirrhosis while 39 had nonviral chronic liver disease. Five (10%) in the former and 1 (2.6%) in the latter group (not significantly different) were positive for HGV RNA in serum. All 6 HGV-infected patients were negative for the presence of the HGV RNA minus strand in the liver when tested with a strand-specific Tth-based reverse transcription-polymerase chain reaction, and 5 were positive for the presence of the plus strand, albeit at low levels. This implies that the liver is not the primary replication site for HGV, at least in a significant proportion of patients. Absence of liver replication explains the reported lack of association between HGV infection and liver pathology encountered in many clinical settings.
AB - It is unclear whether hepatitis G virus (HGV) can lead to chronic liver disease and cirrhosis. Eighty-nine patients with end-stage liver disease undergoing liver transplantation were studied: 50 were diagnosed as having cryptogenic cirrhosis while 39 had nonviral chronic liver disease. Five (10%) in the former and 1 (2.6%) in the latter group (not significantly different) were positive for HGV RNA in serum. All 6 HGV-infected patients were negative for the presence of the HGV RNA minus strand in the liver when tested with a strand-specific Tth-based reverse transcription-polymerase chain reaction, and 5 were positive for the presence of the plus strand, albeit at low levels. This implies that the liver is not the primary replication site for HGV, at least in a significant proportion of patients. Absence of liver replication explains the reported lack of association between HGV infection and liver pathology encountered in many clinical settings.
UR - http://www.scopus.com/inward/record.url?scp=0030695991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030695991&partnerID=8YFLogxK
U2 - 10.1086/514146
DO - 10.1086/514146
M3 - Article
C2 - 9395359
AN - SCOPUS:0030695991
SN - 0022-1899
VL - 176
SP - 1491
EP - 1495
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -