Hepatitis G virus coinfection in hepatitis C virus-infected liver transplant recipients

Hugo E. Vargas, Tomasz Laskus, Marek Radkowski, Anthony Poutous, Lian Fu Wang, Randall Lee, Forest Dodson, Timothy Gayowski, Nina Singh, Ignazio R. Marino, John J. Fung, Zhen Yong Zhang-Keck, Jungsuh P. Kim, Jorge Rakela

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13 Scopus citations

Abstract

Background. In this study, we determined the prevalence of hepatitis G virus (HGV) infection in end-stage hepatitis C virus (HCV)-related liver disease and examined the influence of HGV coinfection on the outcome of liver transplantation. Methods. HGV was detected by reverse transcriptase- polymerase chain reaction and Southern blotting in sera drawn from 159 patients who were known to be HCV infected before transplantation. Patients were followed up for a mean of 28.4 months after transplantation. Results. Forty-one (25.3%) patients were HGV positive and the prevalence of HGV infection was similar for different HCV genotypes. Both HGV-positive and - negative groups had similar survival, recurrence rates, inflammatory activity scores, and degree of fibrosis at the time of recurrence. Conclusion. Infection with HGV is common in end-stage HCV-infected patients presenting for liver transplantation. It influences neither the outcome of liver transplantation nor the recurrence of hepatitis in the graft.

Original languageEnglish (US)
Pages (from-to)786-788
Number of pages3
JournalTransplantation
Volume64
Issue number5
DOIs
StatePublished - Sep 15 1997

ASJC Scopus subject areas

  • Transplantation

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    Vargas, H. E., Laskus, T., Radkowski, M., Poutous, A., Wang, L. F., Lee, R., Dodson, F., Gayowski, T., Singh, N., Marino, I. R., Fung, J. J., Zhang-Keck, Z. Y., Kim, J. P., & Rakela, J. (1997). Hepatitis G virus coinfection in hepatitis C virus-infected liver transplant recipients. Transplantation, 64(5), 786-788. https://doi.org/10.1097/00007890-199709150-00025