Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

Asish K. Ghosh, Robert Steele, Keith Meyer, Ray Ranjit, Ratna B. Ray

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

The phosphoprotein NS5A of hepatitis C virus has recently been suggested to control PKR protein kinase for resistance to interferon. To investigate other functions of NS5A, studies were initiated on the regulation of transcription of important cellular genes and of cell growth by this protein. The results suggested that NS5A protein represses transcription of the cell cycle regulatory gene p21(WAF1), while it activates the human proliferating cell nuclear antigen gene in murine fibroblasts and human hepatoma cells. Furthermore, introduction of NS5A into murine fibroblasts (NIH3T3) promoted anchorage-independent growth and tumour formation in nude mice. Thus, NS5A appears to exhibit a role in cell growth regulation.

Original languageEnglish (US)
Pages (from-to)1179-1183
Number of pages5
JournalJournal of General Virology
Volume80
Issue number5
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Virology

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