Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

Asish K. Ghosh, Robert Steele, Keith Meyer, Ray Ranjit, Ratna B. Ray

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

The phosphoprotein NS5A of hepatitis C virus has recently been suggested to control PKR protein kinase for resistance to interferon. To investigate other functions of NS5A, studies were initiated on the regulation of transcription of important cellular genes and of cell growth by this protein. The results suggested that NS5A protein represses transcription of the cell cycle regulatory gene p21(WAF1), while it activates the human proliferating cell nuclear antigen gene in murine fibroblasts and human hepatoma cells. Furthermore, introduction of NS5A into murine fibroblasts (NIH3T3) promoted anchorage-independent growth and tumour formation in nude mice. Thus, NS5A appears to exhibit a role in cell growth regulation.

Original languageEnglish (US)
Pages (from-to)1179-1183
Number of pages5
JournalJournal of General Virology
Volume80
Issue number5
StatePublished - 1999
Externally publishedYes

Fingerprint

cdc Genes
Regulator Genes
Hepacivirus
Growth
Fibroblasts
eIF-2 Kinase
Phosphoproteins
Proliferating Cell Nuclear Antigen
Nude Mice
Interferons
Genes
Hepatocellular Carcinoma
Proteins
Neoplasms

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Ghosh, A. K., Steele, R., Meyer, K., Ranjit, R., & Ray, R. B. (1999). Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. Journal of General Virology, 80(5), 1179-1183.

Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. / Ghosh, Asish K.; Steele, Robert; Meyer, Keith; Ranjit, Ray; Ray, Ratna B.

In: Journal of General Virology, Vol. 80, No. 5, 1999, p. 1179-1183.

Research output: Contribution to journalArticle

Ghosh, AK, Steele, R, Meyer, K, Ranjit, R & Ray, RB 1999, 'Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth', Journal of General Virology, vol. 80, no. 5, pp. 1179-1183.
Ghosh, Asish K. ; Steele, Robert ; Meyer, Keith ; Ranjit, Ray ; Ray, Ratna B. / Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. In: Journal of General Virology. 1999 ; Vol. 80, No. 5. pp. 1179-1183.
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