Hepatitis C virus and lymphoma

D. S. Viswanatha, A. Dogan

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) is well known for its aetiological role in chronic non-A, non-B viral hepatitis, liver cirrhosis and hepatocellular carcinoma; in addition, the virus has also been implicated in a number of extra-hepatic "autoimmune" disease manifestations. A causative association between HCV and non-Hodgkin lymphoma (NHL) was postulated relatively recently and has been the subject of intense investigation, as well as some debate. On the strength of epidemiological data, emerging biological investigations and clinical observations, HCV appears to be involved in the pathogenesis of at least a proportion of patients with NHL. Morphologically, HCV-associated lymphomas represent a variety of histological subtypes including marginal zone lymphoma (splenic, nodal and extranodal), small lymphocytic lymphoma/chronic lymphocytic leukaemia, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma. Remarkably, some HCV-associated NHL appears to be highly responsive to antiviral therapy, providing some clinical evidence for this relationship, as well as the prospect for novel therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1378-1383
Number of pages6
JournalJournal of Clinical Pathology
Volume60
Issue number12
DOIs
StatePublished - Dec 2007

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Hepacivirus
Lymphoma
Non-Hodgkin's Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Liver Cirrhosis
Hepatitis
Autoimmune Diseases
Antiviral Agents
Hepatocellular Carcinoma
Viruses
Liver
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hepatitis C virus and lymphoma. / Viswanatha, D. S.; Dogan, A.

In: Journal of Clinical Pathology, Vol. 60, No. 12, 12.2007, p. 1378-1383.

Research output: Contribution to journalArticle

Viswanatha, DS & Dogan, A 2007, 'Hepatitis C virus and lymphoma', Journal of Clinical Pathology, vol. 60, no. 12, pp. 1378-1383. https://doi.org/10.1136/jcp.2007.051870
Viswanatha, D. S. ; Dogan, A. / Hepatitis C virus and lymphoma. In: Journal of Clinical Pathology. 2007 ; Vol. 60, No. 12. pp. 1378-1383.
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