Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status

Adrian M. Di Bisceglie, Andre C. Lyra, Myron Schwartz, Rajender K. Reddy, Paul Martin, Gregory James Gores, Anna S F Lok, Khozema B. Hussain, Robert Gish, David H. Van Thiel, Zobair Younossi, Myron Tong, Tarek Hassanein, Luis Balart, Jacquelyn Fleckenstein, Stephen Flamm, Andres Blei, Alex S. Befeler

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Abstract

OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) seems to be rising in the United States (US), and considerable variability in the incidence and etiology of HCC has been noted among different racial and ethnic groups in this country. The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US. METHODS: Retrospective surveys were conducted at liver transplantation centers in the US. Respondents were asked to review the charts of all patients with HCC seen at their institution for the 2-yr period between July, 1997, and June, 1999, and provide information about the racial and ethnic distribution of cases and their serological status with regard to hepatitis B and C markers. RESULTS: Complete information was available on 691 patients who formed the basis of this study, comprising 59% whites, 14% blacks, 16% Asians, and 11% other racial groups. Of the patients, 107 patients (15.4%) were positive for hepatitis B surface antigen (HBsAg), 322 had antibodies to hepatitis C virus (anti-HCV) (46.5%), 33 (4.7%) had both HBsAg and anti-HCV), and 229 (33.1%) had neither marker present. Clear differences were seen among racial groups. Anti-HCV positivity was the most frequent risk factor in both blacks and whites, whereas HBsAg positivity was the most frequent etiological factor in Asians with HCC. CONCLUSIONS: HCV infection seems to be the major risk factor for HCC in the US, particularly among individuals of white and black ethnicity, whereas hepatitis B remains the main risk factor among patients of Asian ethnicity. These preliminary findings indicate the need for a more detailed study of ethnic variability in the pathogenesis of HCC.

Original languageEnglish (US)
Pages (from-to)2060-2063
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume98
Issue number9
StatePublished - Sep 1 2003

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Hepatitis C
Hepatocellular Carcinoma
Hepatitis B Surface Antigens
Hepatitis B
Hepatitis B Antibodies
Hepatitis C Antibodies
Incidence
Ethnic Groups
Hepacivirus
Liver Transplantation
Infection
hydroquinone

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Di Bisceglie, A. M., Lyra, A. C., Schwartz, M., Reddy, R. K., Martin, P., Gores, G. J., ... Befeler, A. S. (2003). Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status. American Journal of Gastroenterology, 98(9), 2060-2063.

Hepatitis C-related hepatocellular carcinoma in the United States : Influence of ethnic status. / Di Bisceglie, Adrian M.; Lyra, Andre C.; Schwartz, Myron; Reddy, Rajender K.; Martin, Paul; Gores, Gregory James; Lok, Anna S F; Hussain, Khozema B.; Gish, Robert; Van Thiel, David H.; Younossi, Zobair; Tong, Myron; Hassanein, Tarek; Balart, Luis; Fleckenstein, Jacquelyn; Flamm, Stephen; Blei, Andres; Befeler, Alex S.

In: American Journal of Gastroenterology, Vol. 98, No. 9, 01.09.2003, p. 2060-2063.

Research output: Contribution to journalArticle

Di Bisceglie, AM, Lyra, AC, Schwartz, M, Reddy, RK, Martin, P, Gores, GJ, Lok, ASF, Hussain, KB, Gish, R, Van Thiel, DH, Younossi, Z, Tong, M, Hassanein, T, Balart, L, Fleckenstein, J, Flamm, S, Blei, A & Befeler, AS 2003, 'Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status', American Journal of Gastroenterology, vol. 98, no. 9, pp. 2060-2063.
Di Bisceglie AM, Lyra AC, Schwartz M, Reddy RK, Martin P, Gores GJ et al. Hepatitis C-related hepatocellular carcinoma in the United States: Influence of ethnic status. American Journal of Gastroenterology. 2003 Sep 1;98(9):2060-2063.
Di Bisceglie, Adrian M. ; Lyra, Andre C. ; Schwartz, Myron ; Reddy, Rajender K. ; Martin, Paul ; Gores, Gregory James ; Lok, Anna S F ; Hussain, Khozema B. ; Gish, Robert ; Van Thiel, David H. ; Younossi, Zobair ; Tong, Myron ; Hassanein, Tarek ; Balart, Luis ; Fleckenstein, Jacquelyn ; Flamm, Stephen ; Blei, Andres ; Befeler, Alex S. / Hepatitis C-related hepatocellular carcinoma in the United States : Influence of ethnic status. In: American Journal of Gastroenterology. 2003 ; Vol. 98, No. 9. pp. 2060-2063.
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abstract = "OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) seems to be rising in the United States (US), and considerable variability in the incidence and etiology of HCC has been noted among different racial and ethnic groups in this country. The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US. METHODS: Retrospective surveys were conducted at liver transplantation centers in the US. Respondents were asked to review the charts of all patients with HCC seen at their institution for the 2-yr period between July, 1997, and June, 1999, and provide information about the racial and ethnic distribution of cases and their serological status with regard to hepatitis B and C markers. RESULTS: Complete information was available on 691 patients who formed the basis of this study, comprising 59{\%} whites, 14{\%} blacks, 16{\%} Asians, and 11{\%} other racial groups. Of the patients, 107 patients (15.4{\%}) were positive for hepatitis B surface antigen (HBsAg), 322 had antibodies to hepatitis C virus (anti-HCV) (46.5{\%}), 33 (4.7{\%}) had both HBsAg and anti-HCV), and 229 (33.1{\%}) had neither marker present. Clear differences were seen among racial groups. Anti-HCV positivity was the most frequent risk factor in both blacks and whites, whereas HBsAg positivity was the most frequent etiological factor in Asians with HCC. CONCLUSIONS: HCV infection seems to be the major risk factor for HCC in the US, particularly among individuals of white and black ethnicity, whereas hepatitis B remains the main risk factor among patients of Asian ethnicity. These preliminary findings indicate the need for a more detailed study of ethnic variability in the pathogenesis of HCC.",
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T1 - Hepatitis C-related hepatocellular carcinoma in the United States

T2 - Influence of ethnic status

AU - Di Bisceglie, Adrian M.

AU - Lyra, Andre C.

AU - Schwartz, Myron

AU - Reddy, Rajender K.

AU - Martin, Paul

AU - Gores, Gregory James

AU - Lok, Anna S F

AU - Hussain, Khozema B.

AU - Gish, Robert

AU - Van Thiel, David H.

AU - Younossi, Zobair

AU - Tong, Myron

AU - Hassanein, Tarek

AU - Balart, Luis

AU - Fleckenstein, Jacquelyn

AU - Flamm, Stephen

AU - Blei, Andres

AU - Befeler, Alex S.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) seems to be rising in the United States (US), and considerable variability in the incidence and etiology of HCC has been noted among different racial and ethnic groups in this country. The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US. METHODS: Retrospective surveys were conducted at liver transplantation centers in the US. Respondents were asked to review the charts of all patients with HCC seen at their institution for the 2-yr period between July, 1997, and June, 1999, and provide information about the racial and ethnic distribution of cases and their serological status with regard to hepatitis B and C markers. RESULTS: Complete information was available on 691 patients who formed the basis of this study, comprising 59% whites, 14% blacks, 16% Asians, and 11% other racial groups. Of the patients, 107 patients (15.4%) were positive for hepatitis B surface antigen (HBsAg), 322 had antibodies to hepatitis C virus (anti-HCV) (46.5%), 33 (4.7%) had both HBsAg and anti-HCV), and 229 (33.1%) had neither marker present. Clear differences were seen among racial groups. Anti-HCV positivity was the most frequent risk factor in both blacks and whites, whereas HBsAg positivity was the most frequent etiological factor in Asians with HCC. CONCLUSIONS: HCV infection seems to be the major risk factor for HCC in the US, particularly among individuals of white and black ethnicity, whereas hepatitis B remains the main risk factor among patients of Asian ethnicity. These preliminary findings indicate the need for a more detailed study of ethnic variability in the pathogenesis of HCC.

AB - OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) seems to be rising in the United States (US), and considerable variability in the incidence and etiology of HCC has been noted among different racial and ethnic groups in this country. The aim of this study was to evaluate the influence of racial and ethnic status in the viral etiology of HCC in the US. METHODS: Retrospective surveys were conducted at liver transplantation centers in the US. Respondents were asked to review the charts of all patients with HCC seen at their institution for the 2-yr period between July, 1997, and June, 1999, and provide information about the racial and ethnic distribution of cases and their serological status with regard to hepatitis B and C markers. RESULTS: Complete information was available on 691 patients who formed the basis of this study, comprising 59% whites, 14% blacks, 16% Asians, and 11% other racial groups. Of the patients, 107 patients (15.4%) were positive for hepatitis B surface antigen (HBsAg), 322 had antibodies to hepatitis C virus (anti-HCV) (46.5%), 33 (4.7%) had both HBsAg and anti-HCV), and 229 (33.1%) had neither marker present. Clear differences were seen among racial groups. Anti-HCV positivity was the most frequent risk factor in both blacks and whites, whereas HBsAg positivity was the most frequent etiological factor in Asians with HCC. CONCLUSIONS: HCV infection seems to be the major risk factor for HCC in the US, particularly among individuals of white and black ethnicity, whereas hepatitis B remains the main risk factor among patients of Asian ethnicity. These preliminary findings indicate the need for a more detailed study of ethnic variability in the pathogenesis of HCC.

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