Hepatitis B virus transcription in the infected liver.

Roberto Cattaneo, H. Will, H. Schaller

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Hepatitis B virus (HBV) transcription was studied in the liver of an infected chimpanzee and compared with HBV transcription in heterologous systems. Besides the well characterized 2.3-kb surface antigen mRNA produced in most systems, a second major transcript was identified in the liver. This 3.8-kb transcript (+/- 300 bases) is slightly larger than the HBV genome and is probably involved both in core/e antigen synthesis and in HBV replication via reverse transcription. In addition, minor variants of the 2.3-kb surface antigen mRNA were characterized as probably being involved in the expression of HBsAg-related minor proteins. Finally, several potential transcription signals, identified on the HBV genome using heterologous expression systems, were found to be poorly active if at all in the infected liver, thereby stressing the importance of HBV transcription studies performed with liver material.

Original languageEnglish (US)
Pages (from-to)2191-2196
Number of pages6
JournalEMBO Journal
Volume3
Issue number9
StatePublished - Sep 1984
Externally publishedYes

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Transcription
Viruses
Hepatitis B virus
Liver
Surface Antigens
Genes
Genome
Messenger RNA
Hepatitis B e Antigens
Pan troglodytes
Hepatitis B Surface Antigens
Virus Replication
Reverse Transcription
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Cattaneo, R., Will, H., & Schaller, H. (1984). Hepatitis B virus transcription in the infected liver. EMBO Journal, 3(9), 2191-2196.

Hepatitis B virus transcription in the infected liver. / Cattaneo, Roberto; Will, H.; Schaller, H.

In: EMBO Journal, Vol. 3, No. 9, 09.1984, p. 2191-2196.

Research output: Contribution to journalArticle

Cattaneo, R, Will, H & Schaller, H 1984, 'Hepatitis B virus transcription in the infected liver.', EMBO Journal, vol. 3, no. 9, pp. 2191-2196.
Cattaneo, Roberto ; Will, H. ; Schaller, H. / Hepatitis B virus transcription in the infected liver. In: EMBO Journal. 1984 ; Vol. 3, No. 9. pp. 2191-2196.
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