Hepatitis-associated aplastic anemia and acute parvovirus B19 infection: A report of two cases and a review of the literature

Darrell S. Pardi, Yvonne Romero, Lester E. Mertz, David D. Douglas

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Abstract

Hepatitis-associated aplastic anemia is rare in general, but occurs in up to 28% of patients receiving liver transplantation for fulminant non-A, non-B hepatitis. Cases are commonly young men with mild hepatitis but severe aplastic anemia. Although cases have been reported in association with hepatitis A, B, and C, most appear to be due to a non-A-B-C virus. We report two cases of acute hepatitis subsequently complicated by marrow hypoplasia in patients with acute parvovirus B19 infection. Hepatic manifestations of parvovirus B19 infection range from liver chemistry abnormalities to fulminant hepatic failure and aplastic anemia. Our cases demonstrate a less severe form of hepatitis-associated aplastic anemia, and together with other data, suggest that parvovirus B19 is at least one cause of hepatitis- associated aplastic anemia, and may be a heretofore underrecognized hepatotrophic virus.

Original languageEnglish (US)
Pages (from-to)468-470
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume93
Issue number3
DOIs
StatePublished - Mar 1998

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Parvoviridae Infections
Aplastic Anemia
Hepatitis
Cercopithecine Herpesvirus 1
Parvovirus
Hepatitis A
Acute Liver Failure
Liver
Hepatitis C
Hepatitis B
Liver Transplantation
Bone Marrow
Viruses

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis-associated aplastic anemia and acute parvovirus B19 infection : A report of two cases and a review of the literature. / Pardi, Darrell S.; Romero, Yvonne; Mertz, Lester E.; Douglas, David D.

In: American Journal of Gastroenterology, Vol. 93, No. 3, 03.1998, p. 468-470.

Research output: Contribution to journalArticle

Pardi, Darrell S. ; Romero, Yvonne ; Mertz, Lester E. ; Douglas, David D. / Hepatitis-associated aplastic anemia and acute parvovirus B19 infection : A report of two cases and a review of the literature. In: American Journal of Gastroenterology. 1998 ; Vol. 93, No. 3. pp. 468-470.
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