Hepatic venous pressure gradient: Worth another look?

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Portal hypertension is one of the most important complications of chronic liver disease and accounts for significant morbidity and mortality. Measurement of the hepatic venous pressure gradient (HVPG) is a simple, invasive, and reproducible method of assessing portal venous pressure. Measurement of HVPG provides the clinician an estimate of the degree of intrahepatic portal flow resistance, guides therapy for variceal bleeding (primary and secondary prophylaxis), assesses feasibility of resection in patients with hepatocellular cancer, and predicts response to therapy of patients with chronic hepatitis C. Achieving hemodynamic targets of reducing the HVPG to <10 mmHg or a 20% reduction from baseline virtually eliminates complications related to portal hypertension from chronic liver disease. This review explores the role of HVPG measurement in the contemporary treatment of patients with cirrhosis and portal hypertension.

Original languageEnglish (US)
Pages (from-to)1178-1183
Number of pages6
JournalDigestive Diseases and Sciences
Volume54
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

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Keywords

  • Cirrhosis
  • Liver function tests
  • Portal hypertension
  • Variceal bleeding

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

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