Hepatic spiral CT: Reduction of dose of intravenous contrast material

James A. Brink, Jay Heiken, Howard P. Forman, Stuart S. Sagel, Paul L. Molina, Paul C. Brown

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

PURPOSE: To assess the potential for reduction of contrast material dose in hepatic spiral computed tomography (CT). MATERIALS AND METHODS: Four hundred eighty-seven outpatients were randomized prospectively into nine biphasic and eight uniphasic injection protocols: 75, 100, or 125 mL of 240, 300, or 350 mg of iodine per milliliter of iohexol (18-44 grams of iodine). Protocols were compared according to the maximum hepatic enhancement (MAX) and the contrast enhancement index (CEI). RESULTS: Uniphasic injection was superior to biphasic injection for all protocols. No statistically significant difference in contrast enhancement was present for 38-44 grams of iodine with the uniphasic technique. Adequate enhancement thresholds (MAX > 50 HU, CEI at 30 HU > 300 HU x sec) were exceeded in more than 70% of heavy patients (>183 lb [83 kg]) with uniphasic injection of 38 g. For thin patients (<183 lb [83 kg]), uniphasic injection of 26 g produced adequate enhancement. CONCLUSION: Contrast material dose may be reduced by up to 40% in thin patients undergoing hepatic spiral CT after uniphasic injection of contrast material; this may result in substantial cost savings.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalRadiology
Volume197
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Spiral Computed Tomography
Contrast Media
Injections
Liver
Iodine
Iohexol
Cost Savings
Outpatients

Keywords

  • Computed tomography (CT), contrast media
  • Computed tomography (CT), helical
  • Iohexol
  • Liver, CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Brink, J. A., Heiken, J., Forman, H. P., Sagel, S. S., Molina, P. L., & Brown, P. C. (1995). Hepatic spiral CT: Reduction of dose of intravenous contrast material. Radiology, 197(1), 83-88. https://doi.org/10.1148/radiology.197.1.7568859

Hepatic spiral CT : Reduction of dose of intravenous contrast material. / Brink, James A.; Heiken, Jay; Forman, Howard P.; Sagel, Stuart S.; Molina, Paul L.; Brown, Paul C.

In: Radiology, Vol. 197, No. 1, 01.01.1995, p. 83-88.

Research output: Contribution to journalArticle

Brink, JA, Heiken, J, Forman, HP, Sagel, SS, Molina, PL & Brown, PC 1995, 'Hepatic spiral CT: Reduction of dose of intravenous contrast material', Radiology, vol. 197, no. 1, pp. 83-88. https://doi.org/10.1148/radiology.197.1.7568859
Brink, James A. ; Heiken, Jay ; Forman, Howard P. ; Sagel, Stuart S. ; Molina, Paul L. ; Brown, Paul C. / Hepatic spiral CT : Reduction of dose of intravenous contrast material. In: Radiology. 1995 ; Vol. 197, No. 1. pp. 83-88.
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