Hepatic sinusoidal endothelial cells

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Hepatic sinusoidal endothelial cells (HSECs) are a morphologically distinct population of cells that form the lining of liver sinusoids. Features that distinguish HSEC from endothelial cells present in other organs and in larger liver vessels are the presence of multiple fenestrae throughout the cells and the lack of an underlying basement membrane [1-4]. The sinusoids are positioned between hepatocyte plates, and they initiate at the portal tract and terminate at the central vein. Sinusoids carry blood that converges in the liver from the portal venous supply as well as from the hepatic artery [5] (Fig. 5.1). Sinusoids are separated from adjacent hepatocytes by the perisinusoidal space of Disse. Due to their position, HSECs are the first cells that are in contact with blood flow into the sinusoids and serve to compartmentalize the vascular sinusoidal channels from the hepatic parenchyma [3, 4]. The hepatic sinusoids range in diameter from 4∈μm near the portal triad to 5.5∈μm near the central vein [6]. As this is smaller than the size of both red and white blood cells, there is distortion of both cells and the sinusoid during the passage of blood cells [6, 7]. This process has been referred to as an endothelial massage that allows efficient exchange of compounds from the blood through sinusoidal fenestrae into the space of Disse [5, 6]. Also residing in the sinusoidal space are hepatic macrophages (Kupffer cells), hepatic natural killer cells (pit cells), and liver-specific pericytes (hepatic stellate cells), each of which are covered in other chapters.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases
PublisherSpringer Berlin Heidelberg
Pages79-91
Number of pages13
ISBN (Print)9783642001499
DOIs
StatePublished - 2010

Fingerprint

Endothelial Cells
Liver
Hepatocytes
Veins
Hepatic Stellate Cells
Pericytes
Kupffer Cells
Massage
Hepatic Artery
Basement Membrane
Natural Killer Cells
Blood Vessels
Blood Cells
Leukocytes
Erythrocytes
Macrophages
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huebert, R. C., & Shah, V. (2010). Hepatic sinusoidal endothelial cells. In Signaling Pathways in Liver Diseases (pp. 79-91). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-00150-5_5

Hepatic sinusoidal endothelial cells. / Huebert, Robert C; Shah, Vijay.

Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, 2010. p. 79-91.

Research output: Chapter in Book/Report/Conference proceedingChapter

Huebert, RC & Shah, V 2010, Hepatic sinusoidal endothelial cells. in Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, pp. 79-91. https://doi.org/10.1007/978-3-642-00150-5_5
Huebert RC, Shah V. Hepatic sinusoidal endothelial cells. In Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg. 2010. p. 79-91 https://doi.org/10.1007/978-3-642-00150-5_5
Huebert, Robert C ; Shah, Vijay. / Hepatic sinusoidal endothelial cells. Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, 2010. pp. 79-91
@inbook{9ea0a60443c84180a9a267a6b65072d5,
title = "Hepatic sinusoidal endothelial cells",
abstract = "Hepatic sinusoidal endothelial cells (HSECs) are a morphologically distinct population of cells that form the lining of liver sinusoids. Features that distinguish HSEC from endothelial cells present in other organs and in larger liver vessels are the presence of multiple fenestrae throughout the cells and the lack of an underlying basement membrane [1-4]. The sinusoids are positioned between hepatocyte plates, and they initiate at the portal tract and terminate at the central vein. Sinusoids carry blood that converges in the liver from the portal venous supply as well as from the hepatic artery [5] (Fig. 5.1). Sinusoids are separated from adjacent hepatocytes by the perisinusoidal space of Disse. Due to their position, HSECs are the first cells that are in contact with blood flow into the sinusoids and serve to compartmentalize the vascular sinusoidal channels from the hepatic parenchyma [3, 4]. The hepatic sinusoids range in diameter from 4∈μm near the portal triad to 5.5∈μm near the central vein [6]. As this is smaller than the size of both red and white blood cells, there is distortion of both cells and the sinusoid during the passage of blood cells [6, 7]. This process has been referred to as an endothelial massage that allows efficient exchange of compounds from the blood through sinusoidal fenestrae into the space of Disse [5, 6]. Also residing in the sinusoidal space are hepatic macrophages (Kupffer cells), hepatic natural killer cells (pit cells), and liver-specific pericytes (hepatic stellate cells), each of which are covered in other chapters.",
author = "Huebert, {Robert C} and Vijay Shah",
year = "2010",
doi = "10.1007/978-3-642-00150-5_5",
language = "English (US)",
isbn = "9783642001499",
pages = "79--91",
booktitle = "Signaling Pathways in Liver Diseases",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Hepatic sinusoidal endothelial cells

AU - Huebert, Robert C

AU - Shah, Vijay

PY - 2010

Y1 - 2010

N2 - Hepatic sinusoidal endothelial cells (HSECs) are a morphologically distinct population of cells that form the lining of liver sinusoids. Features that distinguish HSEC from endothelial cells present in other organs and in larger liver vessels are the presence of multiple fenestrae throughout the cells and the lack of an underlying basement membrane [1-4]. The sinusoids are positioned between hepatocyte plates, and they initiate at the portal tract and terminate at the central vein. Sinusoids carry blood that converges in the liver from the portal venous supply as well as from the hepatic artery [5] (Fig. 5.1). Sinusoids are separated from adjacent hepatocytes by the perisinusoidal space of Disse. Due to their position, HSECs are the first cells that are in contact with blood flow into the sinusoids and serve to compartmentalize the vascular sinusoidal channels from the hepatic parenchyma [3, 4]. The hepatic sinusoids range in diameter from 4∈μm near the portal triad to 5.5∈μm near the central vein [6]. As this is smaller than the size of both red and white blood cells, there is distortion of both cells and the sinusoid during the passage of blood cells [6, 7]. This process has been referred to as an endothelial massage that allows efficient exchange of compounds from the blood through sinusoidal fenestrae into the space of Disse [5, 6]. Also residing in the sinusoidal space are hepatic macrophages (Kupffer cells), hepatic natural killer cells (pit cells), and liver-specific pericytes (hepatic stellate cells), each of which are covered in other chapters.

AB - Hepatic sinusoidal endothelial cells (HSECs) are a morphologically distinct population of cells that form the lining of liver sinusoids. Features that distinguish HSEC from endothelial cells present in other organs and in larger liver vessels are the presence of multiple fenestrae throughout the cells and the lack of an underlying basement membrane [1-4]. The sinusoids are positioned between hepatocyte plates, and they initiate at the portal tract and terminate at the central vein. Sinusoids carry blood that converges in the liver from the portal venous supply as well as from the hepatic artery [5] (Fig. 5.1). Sinusoids are separated from adjacent hepatocytes by the perisinusoidal space of Disse. Due to their position, HSECs are the first cells that are in contact with blood flow into the sinusoids and serve to compartmentalize the vascular sinusoidal channels from the hepatic parenchyma [3, 4]. The hepatic sinusoids range in diameter from 4∈μm near the portal triad to 5.5∈μm near the central vein [6]. As this is smaller than the size of both red and white blood cells, there is distortion of both cells and the sinusoid during the passage of blood cells [6, 7]. This process has been referred to as an endothelial massage that allows efficient exchange of compounds from the blood through sinusoidal fenestrae into the space of Disse [5, 6]. Also residing in the sinusoidal space are hepatic macrophages (Kupffer cells), hepatic natural killer cells (pit cells), and liver-specific pericytes (hepatic stellate cells), each of which are covered in other chapters.

UR - http://www.scopus.com/inward/record.url?scp=78649683336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649683336&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-00150-5_5

DO - 10.1007/978-3-642-00150-5_5

M3 - Chapter

AN - SCOPUS:78649683336

SN - 9783642001499

SP - 79

EP - 91

BT - Signaling Pathways in Liver Diseases

PB - Springer Berlin Heidelberg

ER -