Hepatic MR elastography: Clinical performance in a series of 1377 consecutive examinations1

Meng Yin, Kevin J. Glaser, Jayant A. Talwalkar, Jun Chen, Armando Manduca, Richard Lorne Ehman

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Purpose: To assess the technical success rate and diagnostic performance of liver magnetic resonance (MR) elastography. Materials and Methods: This retrospective study was approved by the institutional review board with patient informed consent. A total of 1377 consecutive MR elastography examinations performed between 2007 and 2010 in 1287 patients for clinical indications were included. Medical records were used to retrieve liver stiffness as assessed with MR elastography, histologic analysis, blood work, and other liver disease-related information. Nonparametric Kruskal-Wallis tests and analysis of covariance methods were used to evaluate the diagnostic values and relationships of the collected data. Results: Hepatic MR elastography had a success rate of 94.4% (1300 of 1377 cases) and yielded reproducible measurements (r = 0.9716, P , .0001) in the study cohort, with a complex patient profile and multiple interpreters. Body mass index had no significant effect on success rate (P = .2). In 289 patients who underwent liver biopsy within 1 year of the MR elastography date, mean liver stiffness as assessed with MR elastography was significantly higher in patients with advanced fibrosis (stages F3, F4) than in those with mild to moderate fibrosis (stages F0, F1, F2) (5.93 kPa 6 2.31 [standard deviation] vs 3.35 kPa 6 1.44, P , .0001). Liver stiffness is associated with many factors other than fibrosis extent, including cause of fibrosis (viral hepatitis C vs nonalcoholic fatty liver disease, P = .025), inflammation (severe vs mild to moderate, P = .03), and hepatic metabolic and synthetic function (no fibrosis vs intermediate fibrosis, P ≤ .01). Conclusion: In a general clinical practice environment, hepatic MR elastography is a robust imaging method with a high success rate in a broad spectrum of patients. It also shows the complex association between liver stiffness and hepatic pathophysiology.

Original languageEnglish (US)
Pages (from-to)114-124
Number of pages11
JournalRadiology
Volume278
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Elasticity Imaging Techniques
Liver
Fibrosis
Research Ethics Committees
Hepatitis C
Informed Consent
General Practice
Medical Records
Liver Diseases
Body Mass Index
Cohort Studies
Retrospective Studies
Inflammation
Biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hepatic MR elastography : Clinical performance in a series of 1377 consecutive examinations1. / Yin, Meng; Glaser, Kevin J.; Talwalkar, Jayant A.; Chen, Jun; Manduca, Armando; Ehman, Richard Lorne.

In: Radiology, Vol. 278, No. 1, 01.01.2016, p. 114-124.

Research output: Contribution to journalArticle

Yin, Meng ; Glaser, Kevin J. ; Talwalkar, Jayant A. ; Chen, Jun ; Manduca, Armando ; Ehman, Richard Lorne. / Hepatic MR elastography : Clinical performance in a series of 1377 consecutive examinations1. In: Radiology. 2016 ; Vol. 278, No. 1. pp. 114-124.
@article{d4eacac11af74157aa0ed359f18d4b5d,
title = "Hepatic MR elastography: Clinical performance in a series of 1377 consecutive examinations1",
abstract = "Purpose: To assess the technical success rate and diagnostic performance of liver magnetic resonance (MR) elastography. Materials and Methods: This retrospective study was approved by the institutional review board with patient informed consent. A total of 1377 consecutive MR elastography examinations performed between 2007 and 2010 in 1287 patients for clinical indications were included. Medical records were used to retrieve liver stiffness as assessed with MR elastography, histologic analysis, blood work, and other liver disease-related information. Nonparametric Kruskal-Wallis tests and analysis of covariance methods were used to evaluate the diagnostic values and relationships of the collected data. Results: Hepatic MR elastography had a success rate of 94.4{\%} (1300 of 1377 cases) and yielded reproducible measurements (r = 0.9716, P , .0001) in the study cohort, with a complex patient profile and multiple interpreters. Body mass index had no significant effect on success rate (P = .2). In 289 patients who underwent liver biopsy within 1 year of the MR elastography date, mean liver stiffness as assessed with MR elastography was significantly higher in patients with advanced fibrosis (stages F3, F4) than in those with mild to moderate fibrosis (stages F0, F1, F2) (5.93 kPa 6 2.31 [standard deviation] vs 3.35 kPa 6 1.44, P , .0001). Liver stiffness is associated with many factors other than fibrosis extent, including cause of fibrosis (viral hepatitis C vs nonalcoholic fatty liver disease, P = .025), inflammation (severe vs mild to moderate, P = .03), and hepatic metabolic and synthetic function (no fibrosis vs intermediate fibrosis, P ≤ .01). Conclusion: In a general clinical practice environment, hepatic MR elastography is a robust imaging method with a high success rate in a broad spectrum of patients. It also shows the complex association between liver stiffness and hepatic pathophysiology.",
author = "Meng Yin and Glaser, {Kevin J.} and Talwalkar, {Jayant A.} and Jun Chen and Armando Manduca and Ehman, {Richard Lorne}",
year = "2016",
month = "1",
day = "1",
doi = "10.1148/radiol.2015142141",
language = "English (US)",
volume = "278",
pages = "114--124",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Hepatic MR elastography

T2 - Clinical performance in a series of 1377 consecutive examinations1

AU - Yin, Meng

AU - Glaser, Kevin J.

AU - Talwalkar, Jayant A.

AU - Chen, Jun

AU - Manduca, Armando

AU - Ehman, Richard Lorne

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose: To assess the technical success rate and diagnostic performance of liver magnetic resonance (MR) elastography. Materials and Methods: This retrospective study was approved by the institutional review board with patient informed consent. A total of 1377 consecutive MR elastography examinations performed between 2007 and 2010 in 1287 patients for clinical indications were included. Medical records were used to retrieve liver stiffness as assessed with MR elastography, histologic analysis, blood work, and other liver disease-related information. Nonparametric Kruskal-Wallis tests and analysis of covariance methods were used to evaluate the diagnostic values and relationships of the collected data. Results: Hepatic MR elastography had a success rate of 94.4% (1300 of 1377 cases) and yielded reproducible measurements (r = 0.9716, P , .0001) in the study cohort, with a complex patient profile and multiple interpreters. Body mass index had no significant effect on success rate (P = .2). In 289 patients who underwent liver biopsy within 1 year of the MR elastography date, mean liver stiffness as assessed with MR elastography was significantly higher in patients with advanced fibrosis (stages F3, F4) than in those with mild to moderate fibrosis (stages F0, F1, F2) (5.93 kPa 6 2.31 [standard deviation] vs 3.35 kPa 6 1.44, P , .0001). Liver stiffness is associated with many factors other than fibrosis extent, including cause of fibrosis (viral hepatitis C vs nonalcoholic fatty liver disease, P = .025), inflammation (severe vs mild to moderate, P = .03), and hepatic metabolic and synthetic function (no fibrosis vs intermediate fibrosis, P ≤ .01). Conclusion: In a general clinical practice environment, hepatic MR elastography is a robust imaging method with a high success rate in a broad spectrum of patients. It also shows the complex association between liver stiffness and hepatic pathophysiology.

AB - Purpose: To assess the technical success rate and diagnostic performance of liver magnetic resonance (MR) elastography. Materials and Methods: This retrospective study was approved by the institutional review board with patient informed consent. A total of 1377 consecutive MR elastography examinations performed between 2007 and 2010 in 1287 patients for clinical indications were included. Medical records were used to retrieve liver stiffness as assessed with MR elastography, histologic analysis, blood work, and other liver disease-related information. Nonparametric Kruskal-Wallis tests and analysis of covariance methods were used to evaluate the diagnostic values and relationships of the collected data. Results: Hepatic MR elastography had a success rate of 94.4% (1300 of 1377 cases) and yielded reproducible measurements (r = 0.9716, P , .0001) in the study cohort, with a complex patient profile and multiple interpreters. Body mass index had no significant effect on success rate (P = .2). In 289 patients who underwent liver biopsy within 1 year of the MR elastography date, mean liver stiffness as assessed with MR elastography was significantly higher in patients with advanced fibrosis (stages F3, F4) than in those with mild to moderate fibrosis (stages F0, F1, F2) (5.93 kPa 6 2.31 [standard deviation] vs 3.35 kPa 6 1.44, P , .0001). Liver stiffness is associated with many factors other than fibrosis extent, including cause of fibrosis (viral hepatitis C vs nonalcoholic fatty liver disease, P = .025), inflammation (severe vs mild to moderate, P = .03), and hepatic metabolic and synthetic function (no fibrosis vs intermediate fibrosis, P ≤ .01). Conclusion: In a general clinical practice environment, hepatic MR elastography is a robust imaging method with a high success rate in a broad spectrum of patients. It also shows the complex association between liver stiffness and hepatic pathophysiology.

UR - http://www.scopus.com/inward/record.url?scp=84952877671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952877671&partnerID=8YFLogxK

U2 - 10.1148/radiol.2015142141

DO - 10.1148/radiol.2015142141

M3 - Article

C2 - 26162026

AN - SCOPUS:84952877671

VL - 278

SP - 114

EP - 124

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -