Hepatic metastases and cavernous hemangiomas: Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging

Donald G. Mitchell, Sanjay Saini, Jeffrey Weinreb, Eduard E. De Lange, Val M. Runge, Janet E. Kuhlman, Yuri Parisky, C. Daniel Johnson, Jeffrey J. Brown, Mitchell Schnall, Robert J. Herfkens, Peter L. Davis, David Gorczyca, Gregg Sica, Gregory S. Foster, Michael E. Bernardino

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine if hepatic metastases can be distinguished from cavernous hemangiomas by pattern analysis of magnetic resonance (MR) images obtained prior to and following administration of gadoteridol at standard (0.1 mmol/kg) and triple (0.3 mmol/kg) doses. MATERIALS AND METHODS: Ninety- five patients with proved hepatic metastases (n = 71) or cavernous hemangiomas (n = 24) underwent MR imaging at 16 different institutions. T2- weighted spin-echo and T1-weighted images were obtained before and after gadoteridol administration. Two independent blinded reviewers rated individual features of benignancy versus malignancy on a five-point confidence scale. RESULTS: The most useful diagnostic features, with 100% specificity, were nodular enhancement for hemangiomas and rim enhancement for metastases. Confident (definitely benign or definitely malignant) diagnoses were rendered in 80 of 95 cases (84%), with an accuracy of a confident diagnosis of 96%. CONCLUSION: The pattern of enhancement on T1-weighted images is highly accurate for distinction between hemangiomas and metastases in images obtained with both doses.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalRadiology
Volume193
Issue number1
DOIs
StatePublished - Jan 1 1994

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Cavernous Hemangioma
Magnetic Resonance Imaging
Neoplasm Metastasis
Liver
Hemangioma
Magnetic Resonance Spectroscopy
gadoteridol
Neoplasms

Keywords

  • Angioma, gastrointestinal system
  • Gadolinium
  • Liver neoplasms, diagnosis
  • Liver neoplasms, secondary
  • Magnetic resonance (MR), pulse sequences
  • Magnetic resonance (MR), tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Mitchell, D. G., Saini, S., Weinreb, J., De Lange, E. E., Runge, V. M., Kuhlman, J. E., ... Bernardino, M. E. (1994). Hepatic metastases and cavernous hemangiomas: Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. Radiology, 193(1), 49-57. https://doi.org/10.1148/radiology.193.1.8090921

Hepatic metastases and cavernous hemangiomas : Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. / Mitchell, Donald G.; Saini, Sanjay; Weinreb, Jeffrey; De Lange, Eduard E.; Runge, Val M.; Kuhlman, Janet E.; Parisky, Yuri; Johnson, C. Daniel; Brown, Jeffrey J.; Schnall, Mitchell; Herfkens, Robert J.; Davis, Peter L.; Gorczyca, David; Sica, Gregg; Foster, Gregory S.; Bernardino, Michael E.

In: Radiology, Vol. 193, No. 1, 01.01.1994, p. 49-57.

Research output: Contribution to journalArticle

Mitchell, DG, Saini, S, Weinreb, J, De Lange, EE, Runge, VM, Kuhlman, JE, Parisky, Y, Johnson, CD, Brown, JJ, Schnall, M, Herfkens, RJ, Davis, PL, Gorczyca, D, Sica, G, Foster, GS & Bernardino, ME 1994, 'Hepatic metastases and cavernous hemangiomas: Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging', Radiology, vol. 193, no. 1, pp. 49-57. https://doi.org/10.1148/radiology.193.1.8090921
Mitchell, Donald G. ; Saini, Sanjay ; Weinreb, Jeffrey ; De Lange, Eduard E. ; Runge, Val M. ; Kuhlman, Janet E. ; Parisky, Yuri ; Johnson, C. Daniel ; Brown, Jeffrey J. ; Schnall, Mitchell ; Herfkens, Robert J. ; Davis, Peter L. ; Gorczyca, David ; Sica, Gregg ; Foster, Gregory S. ; Bernardino, Michael E. / Hepatic metastases and cavernous hemangiomas : Distinction with standard- and triple-dose gadoteridol-enhanced MR imaging. In: Radiology. 1994 ; Vol. 193, No. 1. pp. 49-57.
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abstract = "PURPOSE: To determine if hepatic metastases can be distinguished from cavernous hemangiomas by pattern analysis of magnetic resonance (MR) images obtained prior to and following administration of gadoteridol at standard (0.1 mmol/kg) and triple (0.3 mmol/kg) doses. MATERIALS AND METHODS: Ninety- five patients with proved hepatic metastases (n = 71) or cavernous hemangiomas (n = 24) underwent MR imaging at 16 different institutions. T2- weighted spin-echo and T1-weighted images were obtained before and after gadoteridol administration. Two independent blinded reviewers rated individual features of benignancy versus malignancy on a five-point confidence scale. RESULTS: The most useful diagnostic features, with 100{\%} specificity, were nodular enhancement for hemangiomas and rim enhancement for metastases. Confident (definitely benign or definitely malignant) diagnoses were rendered in 80 of 95 cases (84{\%}), with an accuracy of a confident diagnosis of 96{\%}. CONCLUSION: The pattern of enhancement on T1-weighted images is highly accurate for distinction between hemangiomas and metastases in images obtained with both doses.",
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AU - De Lange, Eduard E.

AU - Runge, Val M.

AU - Kuhlman, Janet E.

AU - Parisky, Yuri

AU - Johnson, C. Daniel

AU - Brown, Jeffrey J.

AU - Schnall, Mitchell

AU - Herfkens, Robert J.

AU - Davis, Peter L.

AU - Gorczyca, David

AU - Sica, Gregg

AU - Foster, Gregory S.

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N2 - PURPOSE: To determine if hepatic metastases can be distinguished from cavernous hemangiomas by pattern analysis of magnetic resonance (MR) images obtained prior to and following administration of gadoteridol at standard (0.1 mmol/kg) and triple (0.3 mmol/kg) doses. MATERIALS AND METHODS: Ninety- five patients with proved hepatic metastases (n = 71) or cavernous hemangiomas (n = 24) underwent MR imaging at 16 different institutions. T2- weighted spin-echo and T1-weighted images were obtained before and after gadoteridol administration. Two independent blinded reviewers rated individual features of benignancy versus malignancy on a five-point confidence scale. RESULTS: The most useful diagnostic features, with 100% specificity, were nodular enhancement for hemangiomas and rim enhancement for metastases. Confident (definitely benign or definitely malignant) diagnoses were rendered in 80 of 95 cases (84%), with an accuracy of a confident diagnosis of 96%. CONCLUSION: The pattern of enhancement on T1-weighted images is highly accurate for distinction between hemangiomas and metastases in images obtained with both doses.

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