Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?

Travis E. Grotz, David Nagorney, John Donohue, Florencia Que, Michael Kendrick, Michael Farnell, Scott Harmsen, David Mulligan, Justin Nguyen, Charles Rosen, Kaye M. Reid-Lombardo

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Background: Hepatic epithelioid haemangioendothelioma (HEH) is a rare vascular neoplasm with unpredictable clinical behaviour. Aim: To compare overall survival (OS) and disease-free survival (DFS) between liver resection (LR) and orthotopic liver transplantation (OLT) for the treatment of HEH. Methods: Retrospective review of 30 patients with HEH treated at Mayo Clinic during 1984 and 2007. Results: Median age was 46 years with a female predominance of 2: 1. Treatment included LR (n= 11), OLT (n= 11), chemotherapy (n= 5) and no treatment (n= 3). LR was associated with a 1-, 3- and 5-year OS of 100%, 86% and 86% and a DFS of 78%, 62% and 62%, respectively. OLT was associated with a 1-, 3- and 5-year OS of 91%, 73% and 73% and a DFS 64%, 46% and 46%, respectively. Metastases were present in 37% of patients but did not significantly affect OS. Important predictors of a favourable OS and DFS were largest tumour ≤ 10 cm and multifocal disease with ≤10 nodules. Conclusion: LR and OLT achieve comparable results in the treatment of HEH. LR is appropriate for patients with resectable disease and favourable prognostic factors. OLT is appropriate for patients with unresectable disease and possibly those with unfavourable prognostic factors. Metastases may not be a contraindication to surgical treatment.

Original languageEnglish (US)
Pages (from-to)546-553
Number of pages8
JournalHPB
Volume12
Issue number8
DOIs
StatePublished - Oct 2010

Keywords

  • chemotherapy < liver
  • resection < liver
  • transplant

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?'. Together they form a unique fingerprint.

Cite this