Hepatic encephalopathy: A dynamic or static condition

Charmaine A. Stewart; Jane Cerhan

doi:10.1007/s11011-005-7207-x

Hepatic encephalopathy: A dynamic or static condition

Charmaine A. Stewart, Jane Cerhan

Psychiatry and Psychology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with portal hypertension. The mechanism of this disorder is still being characterized and the management has relied primarily on lowering the amount of ammonia present in the gastrointestinal tract or reversing liver disease by replacing the diseased liver. It is, however, not established that all the effects of hepatic encephalopathy are reversed by liver transplantation. In this review, we have outlined the mechanisms underlying HE and the pros and cons of reversibility of HE.

Original language	English (US)
Pages (from-to)	193-204
Number of pages	12
Journal	Metabolic Brain Disease
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s11011-005-7207-x
State	Published - Sep 2005

Keywords

Cirrhosis
Cognition in liver disease
Cognitive dysfunction in liver diseases
Decompensated liver disease
Hepatic encephalopathy
Portosystemic encephalopathy

ASJC Scopus subject areas

Biochemistry
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/s11011-005-7207-x

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title = "Hepatic encephalopathy: A dynamic or static condition",

abstract = "Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with portal hypertension. The mechanism of this disorder is still being characterized and the management has relied primarily on lowering the amount of ammonia present in the gastrointestinal tract or reversing liver disease by replacing the diseased liver. It is, however, not established that all the effects of hepatic encephalopathy are reversed by liver transplantation. In this review, we have outlined the mechanisms underlying HE and the pros and cons of reversibility of HE.",

keywords = "Cirrhosis, Cognition in liver disease, Cognitive dysfunction in liver diseases, Decompensated liver disease, Hepatic encephalopathy, Portosystemic encephalopathy",

author = "Stewart, {Charmaine A.} and Jane Cerhan",

note = "Funding Information: Supported in part by grants from the Fiterman Foundation, Mayo Clinic, and the National Institutes of Health (K23DK60018-02).",

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T1 - Hepatic encephalopathy

T2 - A dynamic or static condition

AU - Stewart, Charmaine A.

AU - Cerhan, Jane

N1 - Funding Information: Supported in part by grants from the Fiterman Foundation, Mayo Clinic, and the National Institutes of Health (K23DK60018-02).

PY - 2005/9

Y1 - 2005/9

N2 - Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with portal hypertension. The mechanism of this disorder is still being characterized and the management has relied primarily on lowering the amount of ammonia present in the gastrointestinal tract or reversing liver disease by replacing the diseased liver. It is, however, not established that all the effects of hepatic encephalopathy are reversed by liver transplantation. In this review, we have outlined the mechanisms underlying HE and the pros and cons of reversibility of HE.

AB - Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with portal hypertension. The mechanism of this disorder is still being characterized and the management has relied primarily on lowering the amount of ammonia present in the gastrointestinal tract or reversing liver disease by replacing the diseased liver. It is, however, not established that all the effects of hepatic encephalopathy are reversed by liver transplantation. In this review, we have outlined the mechanisms underlying HE and the pros and cons of reversibility of HE.

KW - Cirrhosis

KW - Cognition in liver disease

KW - Cognitive dysfunction in liver diseases

KW - Decompensated liver disease

KW - Hepatic encephalopathy

KW - Portosystemic encephalopathy

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Hepatic encephalopathy: A dynamic or static condition

Abstract

Keywords

ASJC Scopus subject areas

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