Hepatic arterial reconstruction for orthotopic liver transplantation in the rat

Tomohide Hori, Lindsay B. Gardner, Feng Chen, Ann Marie T. Baine, Toshiyuki Hata, Aimee R. Herdt, Shinji Uemoto, Christopher B. Eckman, Justin H. Nguyen

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: Orthotopic liver transplantation (OLT) models in rats have been investigated in many studies. The reconstruction of hepatic artery is required for reliable OLT and also requires advanced skills. Methods: The hepatic artery reconstructions by a hand-suture technique and a new method using a micro T-tube were investigated in rats with a whole-liver syngeneic graft. Operative time and postoperative patency were compared between the hand-suture and micro T-tube techniques. Results: Our technique using the micro T-tube shortened the operative time of recipient surgery compared with the hand-suture technique and prolonged the operative time for the donor. The patency ratio was maintained at 24 h after OLT with hand suturing but was significantly reduced with the micro T-tube, which had a patency ratio of 0.83 only up to 6 h after OLT. Conclusion: The micro T-tube technique may have potential usefulness in the rat OLT model but requires further modification.

Original languageEnglish (US)
Pages (from-to)907-914
Number of pages8
JournalJournal of Surgical Research
Volume178
Issue number2
DOIs
StatePublished - Dec 1 2012

Keywords

  • Hepatic artery
  • Liver transplantation
  • Microsurgery
  • Surgical instruments

ASJC Scopus subject areas

  • Surgery

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    Hori, T., Gardner, L. B., Chen, F., Baine, A. M. T., Hata, T., Herdt, A. R., Uemoto, S., Eckman, C. B., & Nguyen, J. H. (2012). Hepatic arterial reconstruction for orthotopic liver transplantation in the rat. Journal of Surgical Research, 178(2), 907-914. https://doi.org/10.1016/j.jss.2012.04.039