Hepatic and splenic stiffness augmentation assessed with MR elastography in an in vivo porcine portal hypertension model

Meng Yin, Arunark Kolipaka, David A Woodrum, Kevin J. Glaser, Anthony J. Romano, Armando Manduca, Jayant A. Talwalkar, Philip A Araoz, Kiaran Patrick McGee, Nandan S. Anavekar, Richard Lorne Ehman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose To investigate the influence of portal pressure on the shear stiffness of the liver and spleen in a well-controlled in vivo porcine model with magnetic resonance elastography (MRE). A significant correlation between portal pressure and tissue stiffness could be used to noninvasively assess increased portal venous pressure (portal hypertension), which is a frequent clinical condition caused by cirrhosis of the liver and is responsible for the development of many lethal complications. Materials and Methods During multiple intraarterial infusions of Dextran-40 in three adult domestic pigs in vivo, 3D abdominal MRE was performed with left ventricle and portal catheters measuring blood pressure simultaneously. Least-squares linear regressions were used to analyze the relationship between tissue stiffness and portal pressure. Results Liver and spleen stiffness have a dynamic component that increases significantly following an increase in portal or left ventricular pressure. Correlation coefficients with the linear regressions between stiffness and pressure exceeded 0.8 in most cases. Conclusion The observed stiffness-pressure relationship of the liver and spleen could provide a promising noninvasive method for assessing portal pressure. Using MRE to study the tissue mechanics associated with portal pressure may provide new insights into the natural history and pathophysiology of hepatic diseases and may have significant diagnostic value in the future.

Original languageEnglish (US)
Pages (from-to)809-815
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Elasticity Imaging Techniques
Portal Pressure
Portal Hypertension
Swine
Liver
Spleen
Linear Models
Pressure
Intra Arterial Infusions
Sus scrofa
Ventricular Pressure
Dextrans
Mechanics
Natural History
Least-Squares Analysis
Liver Cirrhosis
Heart Ventricles
Catheters
Blood Pressure

Keywords

  • liver
  • MR elastography
  • portal pressure
  • shear stiffness
  • spleen

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hepatic and splenic stiffness augmentation assessed with MR elastography in an in vivo porcine portal hypertension model. / Yin, Meng; Kolipaka, Arunark; Woodrum, David A; Glaser, Kevin J.; Romano, Anthony J.; Manduca, Armando; Talwalkar, Jayant A.; Araoz, Philip A; McGee, Kiaran Patrick; Anavekar, Nandan S.; Ehman, Richard Lorne.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 4, 10.2013, p. 809-815.

Research output: Contribution to journalArticle

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T1 - Hepatic and splenic stiffness augmentation assessed with MR elastography in an in vivo porcine portal hypertension model

AU - Yin, Meng

AU - Kolipaka, Arunark

AU - Woodrum, David A

AU - Glaser, Kevin J.

AU - Romano, Anthony J.

AU - Manduca, Armando

AU - Talwalkar, Jayant A.

AU - Araoz, Philip A

AU - McGee, Kiaran Patrick

AU - Anavekar, Nandan S.

AU - Ehman, Richard Lorne

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