Hepatic Adenomas: Classification, Controversies, and Consensus

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Rapid advances in molecular and anatomic pathology have greatly improved our understanding of hepatocellular adenomas. Principle among them is a clinically relevant, histology-based classification that identifies hepatic adenomas at greatest risk for malignant transformation. This new classification system has led to general consensus on the major subtypes of hepatic adenomas. However, controversy remains regarding how to incorporate less common types of hepatic adenomas into the classification system and how to incorporate adenoma subtyping into clinical care. This article provides an in-depth review of how adenomas are classified, with a focus on the current rationale, the consensus, and controversies.

Original languageEnglish (US)
Pages (from-to)351-366
Number of pages16
JournalSurgical Pathology Clinics
Volume11
Issue number2
DOIs
StatePublished - Jun 2018

Keywords

  • Androgen adenoma
  • Beta-catenin activated adenoma
  • Classification
  • HNF1 alpha inactivated adenoma
  • Hepatic adenoma
  • Heptaocellular adenoma
  • Histology
  • Inflammatory adenoma
  • Malignant transformation
  • Myxoid adenoma
  • Pathology
  • Pigmented adenoma

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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