Heparin-Induced Thrombocytopenia and Thrombosis in Ischemic Stroke

JOHN L.D. ATKINSON, THORALF M. SUNDT, FRANCIS J. KAZMIER, E. J.WALTER BOWIE, JACK P. WHISNANT

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We reviewed the records of all patients who underwent carotid endarterectomy at our institution during the period from January 1970 through December 1986 to determine the frequency of postoperative occlusions and the role of heparin-induced thrombosis in patients with such occlusions. After 2,527 carotid endarterectomies, a total of 19 occlusions occurred in 18 patients. Of these 18 patients, 6 had an associated heparin-induced coagulation disorder, 3 of whom are described in detail. Although heparin is a useful anticoagulant, it may precipitate occlusion of vessels after an endarterectomy procedure, either at the endarterectomy site or elsewhere. Physicians should be aware of the potentially increased risk for embolic or thrombotic cerebrovascular events in patients who receive heparin therapy.

Original languageEnglish (US)
Pages (from-to)353-361
Number of pages9
JournalMayo Clinic proceedings
Volume63
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Medicine(all)

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