Hemorrhagic Cystitis Complicating Bone Marrow Transplantation

LOUIS LETENDRE, H. CLARK HOAGLAND, Morie Gertz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hemorrhagic cystitis is a potentially serious complication of high-dose cyclophosphamide therapy administered before bone marrow transplantation. As standard practice at our institution, patients who are scheduled to receive a bone marrow transplant are treated prophylactically with forced hydration and bladder irrigation. In an attempt to obviate the inconvenience of bladder irrigation, we conducted a feasibility trial of uroprophylaxis with mesna, which neutralizes the hepatic metabolite of cyclophosphamide that causes hemorrhagic cystitis. Of 97 patients who received standard prophylaxis, 4 had symptomatic hemorrhagic cystitis. In contrast, two of four consecutive patients who received mesna uroprophylaxis before allogeneic bone marrow transplantation had severe hemorrhagic cystitis for at least 2 weeks. Because of this suboptimal result, we resumed the use of bladder irrigation and forced hydration to minimize the risk of hemorrhagic cystitis.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalMayo Clinic Proceedings
Volume67
Issue number2
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Cystitis
Bone Marrow Transplantation
Mesna
Urinary Bladder
Cyclophosphamide
Homologous Transplantation
Bone Marrow
Transplants
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hemorrhagic Cystitis Complicating Bone Marrow Transplantation. / LETENDRE, LOUIS; HOAGLAND, H. CLARK; Gertz, Morie.

In: Mayo Clinic Proceedings, Vol. 67, No. 2, 01.01.1992, p. 128-130.

Research output: Contribution to journalArticle

LETENDRE, LOUIS ; HOAGLAND, H. CLARK ; Gertz, Morie. / Hemorrhagic Cystitis Complicating Bone Marrow Transplantation. In: Mayo Clinic Proceedings. 1992 ; Vol. 67, No. 2. pp. 128-130.
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