Abstract
A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 216-225 |
| Number of pages | 10 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pathology and Forensic Medicine
Cite this
Hemolytic anemia with serum and erythrocyte bound low molecular weight IgM. / Kay, Neil Elliot; Douglas, S. D.; Mond, J. J.; Flier, J. S.; Kochwa, S.; Rosenfield, R. E.
In: Clinical Immunology and Immunopathology, Vol. 4, No. 2, 1975, p. 216-225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemolytic anemia with serum and erythrocyte bound low molecular weight IgM
AU - Kay, Neil Elliot
AU - Douglas, S. D.
AU - Mond, J. J.
AU - Flier, J. S.
AU - Kochwa, S.
AU - Rosenfield, R. E.
PY - 1975
Y1 - 1975
N2 - A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.
AB - A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.
UR - http://www.scopus.com/inward/record.url?scp=84886619459&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886619459&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(00)75170-7
DO - 10.1016/S0040-4039(00)75170-7
M3 - Article
C2 - 806407
AN - SCOPUS:84886619459
VL - 4
SP - 216
EP - 225
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 2
ER -