Hemolytic anemia with serum and erythrocyte bound low molecular weight IgM

Neil Elliot Kay; S. D. Douglas; J. J. Mond; J. S. Flier; S. Kochwa; R. E. Rosenfield

doi:10.1016/S0040-4039(00)75170-7

Hemolytic anemia with serum and erythrocyte bound low molecular weight IgM

Neil Elliot Kay, S. D. Douglas, J. J. Mond, J. S. Flier, S. Kochwa, R. E. Rosenfield

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7 Scopus citations

Abstract

A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

Original language	English (US)
Pages (from-to)	216-225
Number of pages	10
Journal	Clinical Immunology and Immunopathology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0040-4039(00)75170-7
State	Published - 1975
Externally published	Yes

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ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pathology and Forensic Medicine

Cite this

Kay, N. E., Douglas, S. D., Mond, J. J., Flier, J. S., Kochwa, S., & Rosenfield, R. E. (1975). Hemolytic anemia with serum and erythrocyte bound low molecular weight IgM. Clinical Immunology and Immunopathology, 4(2), 216-225. https://doi.org/10.1016/S0040-4039(00)75170-7

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abstract = "A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.",

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AU - Douglas, S. D.

AU - Mond, J. J.

AU - Flier, J. S.

AU - Kochwa, S.

AU - Rosenfield, R. E.

PY - 1975

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AB - A 49 yr old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low molecular weight IgM. The IgM fraction of the patient's serum contained anti I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low molecular weight IgM possibly related to hemolysis in addition to 19S IgM anti I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

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10.1016/S0040-4039(00)75170-7