Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

Neil E. Kay; Steven D. Douglas; James J. Mond; Jeffrey S. Flier; Shaul Kochwa; Richard E. Rosenfield

doi:10.1016/0090-1229(75)90057-4

Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

Neil E. Kay, Steven D. Douglas, James J. Mond, Jeffrey S. Flier, Shaul Kochwa, Richard E. Rosenfield

Hematology

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

Original language	English (US)
Pages (from-to)	216-225
Number of pages	10
Journal	Clinical Immunology and Immunopathology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(75)90057-4
State	Published - Jul 1975

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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Kay, N. E., Douglas, S. D., Mond, J. J., Flier, J. S., Kochwa, S., & Rosenfield, R. E. (1975). Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM. Clinical Immunology and Immunopathology, 4(2), 216-225. https://doi.org/10.1016/0090-1229(75)90057-4

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title = "Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM",

abstract = "A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.",

author = "Kay, {Neil E.} and Douglas, {Steven D.} and Mond, {James J.} and Flier, {Jeffrey S.} and Shaul Kochwa and Rosenfield, {Richard E.}",

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AU - Douglas, Steven D.

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AU - Flier, Jeffrey S.

AU - Kochwa, Shaul

AU - Rosenfield, Richard E.

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AB - A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

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