Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

Neil E. Kay; Steven D. Douglas; James J. Mond; Jeffrey S. Flier; Shaul Kochwa; Richard E. Rosenfield

doi:10.1016/0090-1229(75)90057-4

Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

Neil E. Kay, Steven D. Douglas, James J. Mond, Jeffrey S. Flier, Shaul Kochwa, Richard E. Rosenfield

Hematology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

Original language	English (US)
Pages (from-to)	216-225
Number of pages	10
Journal	Clinical Immunology and Immunopathology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(75)90057-4
State	Published - Jul 1975

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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@article{797c13f8079e4569a6148907bb817691,

title = "Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM",

abstract = "A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.",

author = "Kay, {Neil E.} and Douglas, {Steven D.} and Mond, {James J.} and Flier, {Jeffrey S.} and Shaul Kochwa and Rosenfield, {Richard E.}",

note = "Funding Information: {\textquoteright} Fellow in Immunohematology, Upstate Medical Center, Syracuse, New York I ??I(). {\textquoteright} Supported by Grants AI-12478-01 and HL-05488-I 2 (U.S. Public Health Service), American Lung Association, and National Leukemia Association. Recipient of Research Career Development Award 5KO 4-HL 42.57.(-05.",

year = "1975",

month = jul,

doi = "10.1016/0090-1229(75)90057-4",

language = "English (US)",

volume = "4",

pages = "216--225",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "2",

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T1 - Hemolytic anemia with serum and erythrocyte-bound low-molecular-weight IgM

AU - Kay, Neil E.

AU - Douglas, Steven D.

AU - Mond, James J.

AU - Flier, Jeffrey S.

AU - Kochwa, Shaul

AU - Rosenfield, Richard E.

N1 - Funding Information: ’ Fellow in Immunohematology, Upstate Medical Center, Syracuse, New York I ??I(). ’ Supported by Grants AI-12478-01 and HL-05488-I 2 (U.S. Public Health Service), American Lung Association, and National Leukemia Association. Recipient of Research Career Development Award 5KO 4-HL 42.57.(-05.

PY - 1975/7

Y1 - 1975/7

N2 - A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

AB - A 49-yr-old woman with severe hemolytic anemia had marked depression of serum IgG and IgA along with monoclonal serum IgM detectable in both high and low molecular-weight forms. Antiglobulin tests by instrumented and manual techniques showed only IgM coating of the erythrocytes and an eluate contained low-molecular-weight IgM. The IgM fraction of the patient's serum contained anti-I agglutinins active at 37°C. Lymphocyte response to Concanavalin A was diminished, whereas response to phytohemagglutinin and pokeweed mitogen was normal. Blood monocyte Fc receptor activity was increased in comparison to controls. The finding of a low-molecular-weight IgM possibly related to hemolysis in addition to 19S IgM anti-I activity with high thermal optimum in a patient with hypogammaglobulinemia represents an unusual form of immune hemolytic anemia.

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