Hemodynamic ranges during daily activities and exercise testing in patients with pulmonary arterial hypertension

Barbro Kjellström, Robert Frantz, Raymond L. Benza, Tom Bennett, Robert C. Bourge, Michael D. McGoon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background In patients with pulmonary arterial hypertension (PAH) the relationship between hemodynamic impairment experienced during daily activity and that during exercise testing is not known. Methods and Results Ten PAH patients received an implantable hemodynamic monitor that continuously recorded and stored right ventricular systolic (RVSP) and mean pulmonary arterial (MPAP) pressures. Before starting a new PAH treatment (baseline) and after 12 weeks on treatment, a 6-minute walk test (6MWT) and a maximal walk test (MAXWT) were performed. Exercise pressure range was measured as the difference between rest before exercise and maximal pressure during 6MWT or MAXWT. Ambulatory range (AMB) was measured as the difference between the lowest (4th percentile) and highest (96th percentile) values recorded over 24 hours. One week of AMBs were averaged for each patient before each exercise test. Mean age was 54 ±18 years, 9 were female, and all were in World Health Organization functional class III. At baseline, RVSP and MPAP increased, respectively, 136 ± 49% and 164 ± 49% during AMB, 63 ± 26% and 79 ± 30% during MAXWT, and 59 ± 32% and 69 ± 33% during 6MWT. There was no difference in pressure change at 12 weeks. Conclusions Changes in RV and PA pressures during exercise tests were relatively small compared with the range seen during ambulatory conditions.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalJournal of Cardiac Failure
Volume20
Issue number7
DOIs
StatePublished - 2014

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Pulmonary Hypertension
Hemodynamics
Exercise
Pressure
Exercise Test
Walk Test
Arterial Pressure
Lung
Therapeutics

Keywords

  • 6-minute walk test
  • ambulatory
  • maximal treadmill exercise test
  • Right ventricular pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Hemodynamic ranges during daily activities and exercise testing in patients with pulmonary arterial hypertension. / Kjellström, Barbro; Frantz, Robert; Benza, Raymond L.; Bennett, Tom; Bourge, Robert C.; McGoon, Michael D.

In: Journal of Cardiac Failure, Vol. 20, No. 7, 2014, p. 485-491.

Research output: Contribution to journalArticle

Kjellström, Barbro ; Frantz, Robert ; Benza, Raymond L. ; Bennett, Tom ; Bourge, Robert C. ; McGoon, Michael D. / Hemodynamic ranges during daily activities and exercise testing in patients with pulmonary arterial hypertension. In: Journal of Cardiac Failure. 2014 ; Vol. 20, No. 7. pp. 485-491.
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