Hemodynamic and autonomic effects of smokeless tobacco in healthy young men

Robert Wolk, A. S M Shamsuzzaman, Anna Svatikova, Christine M. Huyber, Corey Huck, Krzysztof Narkiewicz, Virend Somers

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco. BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood. METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 ± 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured. RESULTS: Snuff tobacco increased plasma nicotine from 2.8 ± 0.5 ng/ml to 10.4 ± 1.1 ng/ml. Mean blood pressure increased by 10 ± 1 mm Hg, and heart rate increased by 16 ± 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by ∼50%. CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.

Original languageEnglish (US)
Pages (from-to)910-914
Number of pages5
JournalJournal of the American College of Cardiology
Volume45
Issue number6
DOIs
StatePublished - Mar 15 2005

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Autonomic Agents
Smokeless Tobacco
Hemodynamics
Vascular Resistance
Tobacco
Blood Pressure
Nicotine
Muscles
Epinephrine
Catecholamines
Heart Rate
Placebos
Adrenal Medulla
Tobacco Use
Cross-Over Studies
Norepinephrine
Electrocardiography

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. / Wolk, Robert; Shamsuzzaman, A. S M; Svatikova, Anna; Huyber, Christine M.; Huck, Corey; Narkiewicz, Krzysztof; Somers, Virend.

In: Journal of the American College of Cardiology, Vol. 45, No. 6, 15.03.2005, p. 910-914.

Research output: Contribution to journalArticle

Wolk, R, Shamsuzzaman, ASM, Svatikova, A, Huyber, CM, Huck, C, Narkiewicz, K & Somers, V 2005, 'Hemodynamic and autonomic effects of smokeless tobacco in healthy young men', Journal of the American College of Cardiology, vol. 45, no. 6, pp. 910-914. https://doi.org/10.1016/j.jacc.2004.11.056
Wolk R, Shamsuzzaman ASM, Svatikova A, Huyber CM, Huck C, Narkiewicz K et al. Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. Journal of the American College of Cardiology. 2005 Mar 15;45(6):910-914. https://doi.org/10.1016/j.jacc.2004.11.056
Wolk, Robert ; Shamsuzzaman, A. S M ; Svatikova, Anna ; Huyber, Christine M. ; Huck, Corey ; Narkiewicz, Krzysztof ; Somers, Virend. / Hemodynamic and autonomic effects of smokeless tobacco in healthy young men. In: Journal of the American College of Cardiology. 2005 ; Vol. 45, No. 6. pp. 910-914.
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