TY - JOUR
T1 - Hemodynamic and autonomic effects of smokeless tobacco in healthy young men
AU - Wolk, Robert
AU - Shamsuzzaman, Abu S.M.
AU - Svatikova, Anna
AU - Huyber, Christine M.
AU - Huck, Corey
AU - Narkiewicz, Krzysztof
AU - Somers, Virend K.
PY - 2005/3/15
Y1 - 2005/3/15
N2 - OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco. BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood. METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 ± 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured. RESULTS: Snuff tobacco increased plasma nicotine from 2.8 ± 0.5 ng/ml to 10.4 ± 1.1 ng/ml. Mean blood pressure increased by 10 ± 1 mm Hg, and heart rate increased by 16 ± 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by ∼50%. CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.
AB - OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco. BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood. METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 ± 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured. RESULTS: Snuff tobacco increased plasma nicotine from 2.8 ± 0.5 ng/ml to 10.4 ± 1.1 ng/ml. Mean blood pressure increased by 10 ± 1 mm Hg, and heart rate increased by 16 ± 2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by ∼50%. CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.
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U2 - 10.1016/j.jacc.2004.11.056
DO - 10.1016/j.jacc.2004.11.056
M3 - Article
C2 - 15766828
AN - SCOPUS:14844323642
SN - 0735-1097
VL - 45
SP - 910
EP - 914
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 6
ER -