Heme-oxygenase-2 immunolabelling in pig jejunum

Nilce Mitiko Matsuda; Steven M. Miller; Joseph H. Szurszewski

doi:10.1016/j.acthis.2009.01.001

Heme-oxygenase-2 immunolabelling in pig jejunum

Nilce Mitiko Matsuda, Steven M. Miller, Joseph H. Szurszewski

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers.

Original language	English (US)
Pages (from-to)	402-406
Number of pages	5
Journal	Acta Histochemica
Volume	112
Issue number	4
DOIs	https://doi.org/10.1016/j.acthis.2009.01.001
State	Published - Jul 2010

Keywords

Enteric nervous system
Heme-oxygenase-2
Non-adrenergic and non-cholinergic
Pig jejunum
Smooth muscle

ASJC Scopus subject areas

Histology
Cell Biology

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10.1016/j.acthis.2009.01.001

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title = "Heme-oxygenase-2 immunolabelling in pig jejunum",

abstract = "Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers.",

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AU - Miller, Steven M.

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KW - Smooth muscle

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Heme-oxygenase-2 immunolabelling in pig jejunum

Abstract

Keywords

ASJC Scopus subject areas

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