Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).
|Original language||English (US)|
|Number of pages||5|
|Journal||Nature Clinical Practice Gastroenterology and Hepatology|
|State||Published - Feb 1 2005|
- Portal hypertension
ASJC Scopus subject areas