Hematological malignancy manifesting as ascites

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalNature Clinical Practice Gastroenterology and Hepatology
Volume2
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Hematologic Neoplasms
Ascites
Splenectomy
Surgical Splenorenal Shunt
Digestive System Endoscopy
Dietary Sodium
Paracentesis
Blood Cell Count
Liver
Lost to Follow-Up
Splenomegaly
Portal Hypertension
Vincristine
Prednisone
Diuretics
Thrombocytopenia
Doxorubicin
Cyclophosphamide
Physical Examination
Lymphoma

Keywords

  • Ascites
  • Lymphoma
  • Portal hypertension
  • Splenomegaly

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Hematological malignancy manifesting as ascites. / Lazaridis, Konstantinos N; Abraham, Susan C.; Kamath, Patrick Sequeira.

In: Nature Clinical Practice Gastroenterology and Hepatology, Vol. 2, No. 2, 02.2005, p. 112-116.

Research output: Contribution to journalArticle

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