Hematological malignancy manifesting as ascites

Konstantinos N. Lazaridis; Susan C. Abraham; Patrick S. Kamath

doi:10.1038/ncpgasthep0095

Hematological malignancy manifesting as ascites

Konstantinos N. Lazaridis, Susan C. Abraham, Patrick S. Kamath

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).

Original language	English (US)
Pages (from-to)	112-116
Number of pages	5
Journal	Nature Clinical Practice Gastroenterology and Hepatology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1038/ncpgasthep0095
State	Published - Feb 1 2005

Keywords

Ascites
Lymphoma
Portal hypertension
Splenomegaly

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1038/ncpgasthep0095

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title = "Hematological malignancy manifesting as ascites",

abstract = "Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).",

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T1 - Hematological malignancy manifesting as ascites

AU - Lazaridis, Konstantinos N.

AU - Abraham, Susan C.

AU - Kamath, Patrick S.

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N2 - Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).

AB - Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).

KW - Ascites

KW - Lymphoma

KW - Portal hypertension

KW - Splenomegaly

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Hematological malignancy manifesting as ascites

Abstract

Keywords

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