Hematological malignancy manifesting as ascites

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3 Scopus citations


Background: A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve. Investigations: Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear. Diagnosis: Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites. Management: Paracentesis, dietary sodium restriction and diuretics splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalNature Clinical Practice Gastroenterology and Hepatology
Issue number2
StatePublished - Feb 1 2005


  • Ascites
  • Lymphoma
  • Portal hypertension
  • Splenomegaly

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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