This chapter emphasizes both the morphologic and phenotypic features of the bone marrow in plasma cell myeloma. It details the morphologic features of both trephine biopsies and marrow aspirations. It emphasizes the salient phenotypic features of marrow myeloma cells, in contrast with normal plasma cells. The myeloma cell phenotype is discussed from the perspective of both tissue section immunohistochemistry (IHC) and ﬂow cytometry (FACS analysis). The speciﬁc criteria for myeloma diagnosis are discussed and illustrated in Figs 8.1-8.21. Finally, the differential diagnosis of myeloma is discussed emphasizing the key morphologic and phenotypic diagnostic criteria of each entity.
|Original language||English (US)|
|Title of host publication||Multiple Myeloma and Related Disorders|
|Number of pages||23|
|State||Published - Jan 1 2004|
ASJC Scopus subject areas