Abstract
To study the role of trisomy 21 in hematologic malignancies, we investigated the hematologic disorders of 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome (DS). The most common hematologic malignancy among the patients with acquired trisomy 21 involved both granulocytic and monocytic lineages. By comparison, the hematologic disorders among the DS patients were predominantly acute lymphocytic leukemia and acute megakaryocytic leukemia. Although our sample was small, our results suggest that most patients with acquired trisomy 21 have different hematologic disorders than individuals with DS. Perhaps the role of trisomy 21 in the development of hematologic malignancy is different in constitutional trisomy 21 than it is in acquired trisomy 21.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 247-250 |
| Number of pages | 4 |
| Journal | American Journal of Medical Genetics |
| Issue number | SUPPL. 7 |
| State | Published - 1990 |
Fingerprint
Keywords
- hematologic disorders
- leukemia
- trisomy 21
ASJC Scopus subject areas
- Genetics(clinical)
- Medicine(all)
Cite this
Hematologic disorders in 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome. / Dewald, G. W.; Diez-Martin, J. L.; Steffen, S. L.; Jenkins, Robert Brian; Stupca, P. J.; Burgert, E. O.
In: American Journal of Medical Genetics, No. SUPPL. 7, 1990, p. 247-250.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hematologic disorders in 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome
AU - Dewald, G. W.
AU - Diez-Martin, J. L.
AU - Steffen, S. L.
AU - Jenkins, Robert Brian
AU - Stupca, P. J.
AU - Burgert, E. O.
PY - 1990
Y1 - 1990
N2 - To study the role of trisomy 21 in hematologic malignancies, we investigated the hematologic disorders of 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome (DS). The most common hematologic malignancy among the patients with acquired trisomy 21 involved both granulocytic and monocytic lineages. By comparison, the hematologic disorders among the DS patients were predominantly acute lymphocytic leukemia and acute megakaryocytic leukemia. Although our sample was small, our results suggest that most patients with acquired trisomy 21 have different hematologic disorders than individuals with DS. Perhaps the role of trisomy 21 in the development of hematologic malignancy is different in constitutional trisomy 21 than it is in acquired trisomy 21.
AB - To study the role of trisomy 21 in hematologic malignancies, we investigated the hematologic disorders of 13 patients with acquired trisomy 21 and 13 individuals with Down syndrome (DS). The most common hematologic malignancy among the patients with acquired trisomy 21 involved both granulocytic and monocytic lineages. By comparison, the hematologic disorders among the DS patients were predominantly acute lymphocytic leukemia and acute megakaryocytic leukemia. Although our sample was small, our results suggest that most patients with acquired trisomy 21 have different hematologic disorders than individuals with DS. Perhaps the role of trisomy 21 in the development of hematologic malignancy is different in constitutional trisomy 21 than it is in acquired trisomy 21.
KW - hematologic disorders
KW - leukemia
KW - trisomy 21
UR - http://www.scopus.com/inward/record.url?scp=0025580606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025580606&partnerID=8YFLogxK
M3 - Article
C2 - 2149957
AN - SCOPUS:0025580606
SP - 247
EP - 250
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 0148-7299
IS - SUPPL. 7
ER -