Hematologic disorders associated with deletions of chromosome 20q: A clinicopathologic study of 107 patients

Paul J. Kurtin, Gordon W. Dewald, David J. Shields, Curtis A. Hanson

Research output: Contribution to journalArticle

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Abstract

To study the pathogenetic significance of acquired del(20q), bone marrow morphology and clinical histories of 107 patients with hematologic disorders and the del(20q) were studied. In 84 cases representing myelodysplastic syndromes (47), myeloproliferative disorders (31), acute myeloid leukemia (3), pure red blood cell aplasia (2), and angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)-like T-cell lymphoma (1), 20q- was the sole karyotypic abnormality. The breakpoints on chromosome 20 were not constant, and in 77% of cases, only a fraction of the studied metaphases had del(20q). In 23 cases, including myelodysplastic syndromes (13), myeloproliferative disorders (6), acute myeloid leukemia (2), and autoimmune disorders (2), 20q- occurred with other cytogenetic abnormalities, including del(5q), -7, +8, 13q deletion or translocation, and +21. Despite the diagnostic heterogeneity, the bone marrow morphologic abnormalities consistently involved the erythroid precursors and megakaryocytes. 20q- is a primary cytogenetic abnormality occurring in hematologic disorders unified morphologically by dysplasia in erythroid precursors and megakaryocytes. In conjunction with other studies of disorders involving del(20q) or genes on the long arm of chromosome 20, the findings suggest that del(20q) disproportionately affects a common megakaryocytic/RBC stem cell.

Original languageEnglish (US)
Pages (from-to)680-688
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume106
Issue number5
StatePublished - Nov 1996

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Chromosomes, Human, Pair 20
Myeloproliferative Disorders
Chromosome Deletion
Megakaryocytes
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Chromosome Aberrations
Bone Marrow
Immunoblastic Lymphadenopathy
Pure Red-Cell Aplasia
T-Cell Lymphoma
Metaphase
Stem Cells
Erythrocytes
Genes
13q deletion syndrome

Keywords

  • Acute leukemia
  • Bone marrow
  • Cytogenetics
  • Del(20q)
  • Myelodysplastic syndromes
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hematologic disorders associated with deletions of chromosome 20q : A clinicopathologic study of 107 patients. / Kurtin, Paul J.; Dewald, Gordon W.; Shields, David J.; Hanson, Curtis A.

In: American Journal of Clinical Pathology, Vol. 106, No. 5, 11.1996, p. 680-688.

Research output: Contribution to journalArticle

Kurtin, Paul J. ; Dewald, Gordon W. ; Shields, David J. ; Hanson, Curtis A. / Hematologic disorders associated with deletions of chromosome 20q : A clinicopathologic study of 107 patients. In: American Journal of Clinical Pathology. 1996 ; Vol. 106, No. 5. pp. 680-688.
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