Helicobacter pylori in North and South America before Columbus

Yoshio Yamaoka; Etsuro Orito; Masashi Mizokami; Oscar Gutierrez; Naruya Saitou; Tadashi Kodama; Michael S. Osato; Jong G. Kim; Francisco C. Ramirez; Varocha Mahachai; David Y. Graham

doi:10.1016/S0014-5793(02)02617-0

Helicobacter pylori in North and South America before Columbus

Yoshio Yamaoka, Etsuro Orito, Masashi Mizokami, Oscar Gutierrez, Naruya Saitou, Tadashi Kodama, Michael S. Osato, Jong G. Kim, Francisco C. Ramirez, Varocha Mahachai, David Y. Graham

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

We present a molecular epidemiologic study, based on an analysis of vacA, cagA and cag right end junction genotypes from 1042 Helicobacter pylori isolates, suggesting that H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel vacA and/or cagA gene structures and were more closely related to East Asian than to non-Asian H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times.

Original language	English (US)
Pages (from-to)	180-184
Number of pages	5
Journal	FEBS Letters
Volume	517
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(02)02617-0
State	Published - Apr 24 2002

Keywords

Helicobacter pylori
Native American
cagA gene
vacA gene

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(02)02617-0

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title = "Helicobacter pylori in North and South America before Columbus",

abstract = "We present a molecular epidemiologic study, based on an analysis of vacA, cagA and cag right end junction genotypes from 1042 Helicobacter pylori isolates, suggesting that H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel vacA and/or cagA gene structures and were more closely related to East Asian than to non-Asian H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times.",

keywords = "Helicobacter pylori, Native American, cagA gene, vacA gene",

author = "Yoshio Yamaoka and Etsuro Orito and Masashi Mizokami and Oscar Gutierrez and Naruya Saitou and Tadashi Kodama and Osato, {Michael S.} and Kim, {Jong G.} and Ramirez, {Francisco C.} and Varocha Mahachai and Graham, {David Y.}",

note = "Funding Information: We thank J. Parkinson (Alaska), C.L. Perng (Taiwan), J.Y. Sung (Hong Kong), R.N. Agnes Walsh (Thailand), Z. Nurgalieva (Kazakhstan), G. Realdi (Italy), A. Simjee (South Africa), J.J. Pedrazzoli (Brazil), and S. Mendonca (Brazil) for H. pylori strains. We thank M. Gomez (Colombia) for assistance in obtaining samples from Native Colombians. This material is based upon work supported in part by the Office of Research and Development Medical Research Service Department of Veterans Affairs and by Public Health Service Grant DK-53659. We also acknowledge the generous support of Hilda Schwartz.",

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AU - Yamaoka, Yoshio

AU - Orito, Etsuro

AU - Mizokami, Masashi

AU - Gutierrez, Oscar

AU - Saitou, Naruya

AU - Kodama, Tadashi

AU - Osato, Michael S.

AU - Kim, Jong G.

AU - Ramirez, Francisco C.

AU - Mahachai, Varocha

AU - Graham, David Y.

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PY - 2002/4/24

Y1 - 2002/4/24

N2 - We present a molecular epidemiologic study, based on an analysis of vacA, cagA and cag right end junction genotypes from 1042 Helicobacter pylori isolates, suggesting that H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel vacA and/or cagA gene structures and were more closely related to East Asian than to non-Asian H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times.

AB - We present a molecular epidemiologic study, based on an analysis of vacA, cagA and cag right end junction genotypes from 1042 Helicobacter pylori isolates, suggesting that H. pylori was present in the New World before Columbus. Eight Native Colombian and Alaskan strains possessed novel vacA and/or cagA gene structures and were more closely related to East Asian than to non-Asian H. pylori. Some Native Alaskan strains appear to have originated in Central Asia and to have arrived after strains found in South America suggesting that H. pylori crossed the Bering Strait from Asia to the New World at different times.

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Helicobacter pylori in North and South America before Columbus

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Keywords

ASJC Scopus subject areas

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