Hedgehog Pathway Inhibition

Aleksandar D Sekulic, Daniel Von Hoff

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).

Original languageEnglish (US)
Pages (from-to)831
Number of pages1
JournalCell
Volume164
Issue number5
DOIs
StatePublished - Feb 25 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Hedgehog Pathway Inhibition'. Together they form a unique fingerprint.

  • Cite this