Hedgehog Pathway Inhibition

Aleksandar Sekulic, Daniel Von Hoff

Research output: Contribution to journalShort surveypeer-review

32 Scopus citations


The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).

Original languageEnglish (US)
Pages (from-to)831
Number of pages1
Issue number5
StatePublished - Feb 25 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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