Heck’s disease occurring after Epstein-Barr virus-associated smooth muscle tumors in an immunosuppressed child

Natasha Arbelo-Ramos; Katelyn Anderson; Avni Joshi; Carilyn Wieland; Stephen Tyring; Peter Rady; Megha Tollefson

doi:10.1111/pde.14463

Heck’s disease occurring after Epstein-Barr virus-associated smooth muscle tumors in an immunosuppressed child

Natasha Arbelo-Ramos, Katelyn Anderson, Avni Joshi, Carilyn Wieland, Stephen Tyring, Peter Rady, Megha Tollefson

Dermatology

Research output: Contribution to journal › Article › peer-review

Abstract

A 10-year-old Guatemalan girl with past medical history of Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) and combined immunodeficiency presented for evaluation of painful intraoral lesions. On examination, she was noted to have multiple, white to flesh-colored, soft, flat-topped papules, and plaques on the buccal and labial mucosa. Human papillomavirus type 13 was detected on PCR with PGMY primers of previously biopsied buccal tissue, confirming a diagnosis of Heck's disease (multifocal epithelial hyperplasia). We present an immunosuppressed, pediatric patient with two rare, virus-associated neoplastic disorders that have not been previously reported to occur in the same individual.

Original language	English (US)
Pages (from-to)	257-259
Number of pages	3
Journal	Pediatric Dermatology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1111/pde.14463
State	Published - Jan 1 2021

Keywords

Epstein-Barr virus
Heck's disease
focal epithelial hyperplasia
human papillomavirus
immunodeficiency

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Dermatology

Access to Document

10.1111/pde.14463

Cite this

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abstract = "A 10-year-old Guatemalan girl with past medical history of Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) and combined immunodeficiency presented for evaluation of painful intraoral lesions. On examination, she was noted to have multiple, white to flesh-colored, soft, flat-topped papules, and plaques on the buccal and labial mucosa. Human papillomavirus type 13 was detected on PCR with PGMY primers of previously biopsied buccal tissue, confirming a diagnosis of Heck's disease (multifocal epithelial hyperplasia). We present an immunosuppressed, pediatric patient with two rare, virus-associated neoplastic disorders that have not been previously reported to occur in the same individual.",

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AU - Arbelo-Ramos, Natasha

AU - Anderson, Katelyn

AU - Joshi, Avni

AU - Wieland, Carilyn

AU - Tyring, Stephen

AU - Rady, Peter

AU - Tollefson, Megha

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Heck’s disease occurring after Epstein-Barr virus-associated smooth muscle tumors in an immunosuppressed child

Abstract

Keywords

ASJC Scopus subject areas

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