Heck’s disease occurring after Epstein-Barr virus-associated smooth muscle tumors in an immunosuppressed child

Natasha Arbelo-Ramos, Katelyn Anderson, Avni Joshi, Carilyn Wieland, Stephen Tyring, Peter Rady, Megha Tollefson

Research output: Contribution to journalArticlepeer-review

Abstract

A 10-year-old Guatemalan girl with past medical history of Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) and combined immunodeficiency presented for evaluation of painful intraoral lesions. On examination, she was noted to have multiple, white to flesh-colored, soft, flat-topped papules, and plaques on the buccal and labial mucosa. Human papillomavirus type 13 was detected on PCR with PGMY primers of previously biopsied buccal tissue, confirming a diagnosis of Heck's disease (multifocal epithelial hyperplasia). We present an immunosuppressed, pediatric patient with two rare, virus-associated neoplastic disorders that have not been previously reported to occur in the same individual.

Original languageEnglish (US)
Pages (from-to)257-259
Number of pages3
JournalPediatric Dermatology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2021

Keywords

  • Epstein-Barr virus
  • Heck's disease
  • focal epithelial hyperplasia
  • human papillomavirus
  • immunodeficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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