Heart transplantation for radiation-associated end-stage heart failure

Nobuhiro Handa, Christopher G.A. McGregor, Richard C. Daly, Joseph A. Dearani, Brooks S. Edwards, Robert P. Frantz, Lyle J. Olson, Richard J. Rodeheffer

Research output: Contribution to journalArticle

18 Scopus citations


Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalTransplant International
Issue number2
StatePublished - Mar 2000


  • Heart transplantation
  • Radiation-induced heart disease

ASJC Scopus subject areas

  • Transplantation

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  • Cite this

    Handa, N., McGregor, C. G. A., Daly, R. C., Dearani, J. A., Edwards, B. S., Frantz, R. P., Olson, L. J., & Rodeheffer, R. J. (2000). Heart transplantation for radiation-associated end-stage heart failure. Transplant International, 13(2), 162-165. https://doi.org/10.1111/j.1432-2277.2000.tb01058.x