TY - JOUR
T1 - Heart rate recovery and prognosis in heart failure patients
AU - Kubrychtova, Vera
AU - Olson, Thomas P.
AU - Bailey, Kent R.
AU - Thapa, Prabin
AU - Allison, Thomas G.
AU - Johnson, Bruce D.
N1 - Funding Information:
Acknowledgments We would like to thank Kathy O’Malley and Minelle Hulsebus for their help with data collection and Renee Blu-mers for her help in manuscript preparation. This work was supported by National Institutes of Health grants: HL71478 and HL07111. Vera Kubrychtova, a visiting graduate student from Charles University in
Funding Information:
Prague, Czech Republic was supported by Charles University in Prague, Czech Republic and the Mayo Foundation.
PY - 2009
Y1 - 2009
N2 - The aim of this study is to evaluate the usefulness of heart rate recovery (HRRec) for assessing risk of death in heart failure (HF) patients. Echocardiographic and clinical exercise data were analyzed retrospectively on 712 HF patients (EF ≤ 45%). HRRec was calculated as peak exercise heart rate - heart rate at 1 min of active recovery. Patients were followed for all-cause mortality (5.9 ± 3.3 years follow-up). Groups were identified according to HRRec: group-1 (HRR ≤ 4 bpm), group-2 (5 ≤ HRR ≤ 9 bpm), and group-3 (HRR ≥ 10). Kaplan-Meier analysis estimated survival of 91, 64, and 43% (group-1); 94, 76, and 63% (group-2); and 92, 82, and 70% (group-3) at 1, 5, and 10 years, respectively. Ranked HRRec independently predicted mortality after adjusting for age, gender, NYHA class, LVEF and BMI, but was not independent of exercise time, peak VO2VE/ VCO2 at nadir. HRRec is a useful prognostic marker in patients with HF, particularly when gas exchange measures are not available.
AB - The aim of this study is to evaluate the usefulness of heart rate recovery (HRRec) for assessing risk of death in heart failure (HF) patients. Echocardiographic and clinical exercise data were analyzed retrospectively on 712 HF patients (EF ≤ 45%). HRRec was calculated as peak exercise heart rate - heart rate at 1 min of active recovery. Patients were followed for all-cause mortality (5.9 ± 3.3 years follow-up). Groups were identified according to HRRec: group-1 (HRR ≤ 4 bpm), group-2 (5 ≤ HRR ≤ 9 bpm), and group-3 (HRR ≥ 10). Kaplan-Meier analysis estimated survival of 91, 64, and 43% (group-1); 94, 76, and 63% (group-2); and 92, 82, and 70% (group-3) at 1, 5, and 10 years, respectively. Ranked HRRec independently predicted mortality after adjusting for age, gender, NYHA class, LVEF and BMI, but was not independent of exercise time, peak VO2VE/ VCO2 at nadir. HRRec is a useful prognostic marker in patients with HF, particularly when gas exchange measures are not available.
KW - Clinical exercise testing
KW - Dyspnea
KW - Fatigue
KW - Oxygen consumption
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U2 - 10.1007/s00421-008-0870-z
DO - 10.1007/s00421-008-0870-z
M3 - Article
C2 - 18797918
AN - SCOPUS:58549109816
SN - 1439-6319
VL - 105
SP - 37
EP - 45
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 1
ER -