TY - JOUR
T1 - Heart Failure with Preserved Ejection Fraction
T2 - Mechanisms and Treatment Strategies
AU - Omote, Kazunori
AU - Verbrugge, Frederik H.
AU - Borlaug, Barry A.
N1 - Publisher Copyright:
© 2022 Annual Reviews Inc.. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Approximately half of all patients with heart failure (HF) have a preserved ejection fraction, and the prevalence is growing rapidly given the aging population in many countries and the rising prevalence of obesity, diabetes, and hypertension. Functional capacity and quality of life are severely impaired in heart failure with preserved ejection fraction (HFpEF), and morbidity and mortality are high. In striking contrast to HF with reduced ejection fraction, there are few effective treatments currently identified for HFpEF, and these are limited to decongestion by diuretics, promotion of a healthy active lifestyle, and management of comorbidities. Improved phenotyping of subgroups within the overall HFpEF population might enhance individualization of treatment. This review focuses on the current understanding of the pathophysiologic mechanisms underlying HFpEF and treatment strategies for this complex syndrome.
AB - Approximately half of all patients with heart failure (HF) have a preserved ejection fraction, and the prevalence is growing rapidly given the aging population in many countries and the rising prevalence of obesity, diabetes, and hypertension. Functional capacity and quality of life are severely impaired in heart failure with preserved ejection fraction (HFpEF), and morbidity and mortality are high. In striking contrast to HF with reduced ejection fraction, there are few effective treatments currently identified for HFpEF, and these are limited to decongestion by diuretics, promotion of a healthy active lifestyle, and management of comorbidities. Improved phenotyping of subgroups within the overall HFpEF population might enhance individualization of treatment. This review focuses on the current understanding of the pathophysiologic mechanisms underlying HFpEF and treatment strategies for this complex syndrome.
KW - Heart failure
KW - Heart failure with preserved ejection fraction
KW - Pathophysiology
KW - Treatment
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U2 - 10.1146/annurev-med-042220-022745
DO - 10.1146/annurev-med-042220-022745
M3 - Review article
C2 - 34379445
AN - SCOPUS:85123690763
SN - 0066-4219
VL - 73
SP - 321
EP - 337
JO - Annual Review of Medicine
JF - Annual Review of Medicine
ER -