Heart Failure with Preserved Ejection Fraction

James D. Gladden, Antoine H. Chaanine, Margaret M. Redfield

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Heart failure (HF) is a clinical syndrome of diverse etiologies and can be associated with preserved, reduced, or mid-range ejection fraction (EF). In the community, heart failure with preserved ejection fraction (HFpEF) is emerging as the most common form of HF. There remains considerable uncertainty regarding its pathogenesis, diagnosis, and optimal therapeutic approach. Hypotheses have been advanced to explain the underlying pathophysiology responsible for HFpEF, but to date, no specific therapy based on these hypotheses has been proven to improve outcomes in HFpEF. We provide a clinically focused review of the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of HFpEF.

Original languageEnglish (US)
Pages (from-to)65-79
Number of pages15
JournalAnnual Review of Medicine
StatePublished - Jan 29 2018


  • Cardiomyopathy
  • Diastolic heart failure
  • Hypertension
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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