TY - JOUR
T1 - Heart Failure with Preserved Ejection Fraction
AU - Gladden, James D.
AU - Chaanine, Antoine H.
AU - Redfield, Margaret M.
N1 - Publisher Copyright:
Copyright ©2018 by Annual Reviews. All rights reserved.
PY - 2018/1/29
Y1 - 2018/1/29
N2 - Heart failure (HF) is a clinical syndrome of diverse etiologies and can be associated with preserved, reduced, or mid-range ejection fraction (EF). In the community, heart failure with preserved ejection fraction (HFpEF) is emerging as the most common form of HF. There remains considerable uncertainty regarding its pathogenesis, diagnosis, and optimal therapeutic approach. Hypotheses have been advanced to explain the underlying pathophysiology responsible for HFpEF, but to date, no specific therapy based on these hypotheses has been proven to improve outcomes in HFpEF. We provide a clinically focused review of the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of HFpEF.
AB - Heart failure (HF) is a clinical syndrome of diverse etiologies and can be associated with preserved, reduced, or mid-range ejection fraction (EF). In the community, heart failure with preserved ejection fraction (HFpEF) is emerging as the most common form of HF. There remains considerable uncertainty regarding its pathogenesis, diagnosis, and optimal therapeutic approach. Hypotheses have been advanced to explain the underlying pathophysiology responsible for HFpEF, but to date, no specific therapy based on these hypotheses has been proven to improve outcomes in HFpEF. We provide a clinically focused review of the epidemiology, clinical presentation, diagnostic approach, pathophysiology, and treatment of HFpEF.
KW - Cardiomyopathy
KW - Diastolic heart failure
KW - Hypertension
KW - Pulmonary hypertension
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U2 - 10.1146/annurev-med-041316-090654
DO - 10.1146/annurev-med-041316-090654
M3 - Review article
C2 - 29414252
AN - SCOPUS:85041712583
SN - 0066-4219
VL - 69
SP - 65
EP - 79
JO - Annual Review of Medicine
JF - Annual Review of Medicine
ER -